Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TBXA2R | P21731 | 7/20 | 0.39 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.37 |
| ▸ | SCN9A | Q15858 | 3/20 | 0.35 |
| ▸ | PLA2G7 | Q13093 | 1/20 | 0.34 |
| ▸ | SLC22A12 | Q96S37 | 2/20 | 0.34 |
| ▸ | EGLN2 | Q96KS0 | 1/20 | 0.34 |
| ▸ | MGLL | Q99685 | 2/20 | 0.32 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.32 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.32 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.32 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.32 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.32 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.32 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.32 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4370906 | 0.91 | SCN9A (0.36) | TBXA2RSCN9A | |
| SCHEMBL4375795 | 0.89 | TBXA2R (0.34) | TBXA2RTRPV4SCN9APSEN1PSEN2 | |
| SCHEMBL4371687 | 0.89 | SMN1; SMN2 (0.36) | SCN9AEGLN2 | |
| SCHEMBL1804010 | 0.86 | CARM1 (0.35) | TBXA2R | |
| SCHEMBL4377327 | 0.81 | F2 (0.39) | CACNA1HCACNA1B | |
| SCHEMBL1799336 | 0.81 | F2 (0.34) | — | |
| SCHEMBL3874559 | 0.80 | NPY4R (0.36) | — | |
| SCHEMBL1799060 | 0.79 | SLC9A3 (0.36) | — | |
| SCHEMBL1800587 | 0.79 | SLC9A3 (0.33) | TRPV4PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL4372241 | 0.79 | ADAM17 (0.49) | TBXA2R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1461313-B1 | HUMAN ADAM-10 INHIBITORS | EXELIXIS INC (US) | 2009-08-05 | — | — | EP | claimed |
| EP-1461313-B1 | HUMAN ADAM-10 INHIBITORS | EXELIXIS INC (US) | 2009-08-05 | — | — | EP | disclosed |