Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F2 | P00734 | 2/20 | 0.39 |
| ▸ | PRSS1 | P07477 | 2/20 | 0.39 |
| ▸ | PRSS2 | P07478 | 2/20 | 0.39 |
| ▸ | PRSS3 | P35030 | 2/20 | 0.39 |
| ▸ | ST14 | Q9Y5Y6 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.37 |
| ▸ | MMP1 | P03956 | 3/20 | 0.36 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.35 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | MMP2 | P08253 | 5/20 | 0.34 |
| ▸ | MMP9 | P14780 | 3/20 | 0.34 |
| ▸ | MMP13 | P45452 | 2/20 | 0.34 |
| ▸ | TAS2R14 | Q9NYV8 | 1/20 | 0.34 |
| ▸ | CA12 | O43570 | 2/20 | 0.33 |
| ▸ | CA1 | P00915 | 2/20 | 0.33 |
| ▸ | CA2 | P00918 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4375791 | 0.91 | MMP2 (0.42) | MMP1MMP2MMP9MMP13CA12 | |
| SCHEMBL4370906 | 0.90 | SCN9A (0.36) | F2PRSS1PRSS2PRSS3ST14 | |
| SCHEMBL1799336 | 0.90 | F2 (0.34) | F2PRSS1PRSS2PRSS3ST14 | |
| SCHEMBL1800832 | 0.89 | F2 (0.37) | F2PRSS1PRSS2PRSS3ST14 | |
| SCHEMBL4372258 | 0.85 | F2 (0.41) | F2PRSS1PRSS2PRSS3ST14 | |
| SCHEMBL3874559 | 0.83 | NPY4R (0.36) | — | |
| SCHEMBL3879230 | 0.83 | MMP2 (0.44) | RAB9ASOS1MMP1FFAR1NR3C1 | |
| SCHEMBL4375795 | 0.83 | TBXA2R (0.34) | PRSS1SOS1CA12CA1CA2 | |
| SCHEMBL1799060 | 0.82 | SLC9A3 (0.36) | MMP2MMP9MMP14 | |
| SCHEMBL4371687 | 0.82 | SMN1; SMN2 (0.36) | PRSS1MMP2MMP9MMP13CA12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1461313-B1 | HUMAN ADAM-10 INHIBITORS | EXELIXIS INC (US) | 2009-08-05 | — | — | EP | claimed |
| EP-1461313-B1 | HUMAN ADAM-10 INHIBITORS | EXELIXIS INC (US) | 2009-08-05 | — | — | EP | disclosed |