Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CARM1 | Q86X55 | 2/20 | 0.35 |
| ▸ | PRMT6 | Q96LA8 | 2/20 | 0.35 |
| ▸ | PRSS1 | P07477 | 2/20 | 0.35 |
| ▸ | TMPRSS15 | P98073 | 2/20 | 0.35 |
| ▸ | CA12 | O43570 | 1/20 | 0.34 |
| ▸ | CA1 | P00915 | 1/20 | 0.34 |
| ▸ | CA2 | P00918 | 1/20 | 0.34 |
| ▸ | CA9 | Q16790 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.32 |
| ▸ | TBXA2R | P21731 | 4/20 | 0.31 |
| ▸ | REN | P00797 | 1/20 | 0.31 |
| ▸ | MRGPRX1 | Q96LB2 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.31 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4371687 | 0.90 | SMN1; SMN2 (0.36) | PRSS1TMPRSS15CA12CA1CA2 | |
| SCHEMBL4370906 | 0.90 | SCN9A (0.36) | CARM1PRMT6PRSS1TMPRSS15CA12 | |
| SCHEMBL4375795 | 0.88 | TBXA2R (0.34) | PRSS1TMPRSS15CA12CA1CA2 | |
| SCHEMBL4372245 | 0.86 | TBXA2R (0.39) | TBXA2R | |
| SCHEMBL4377327 | 0.79 | F2 (0.39) | PRSS1CA12CA1CA2CA9 | |
| SCHEMBL4293042 | 0.79 | LTA4H (0.33) | CA12CA1CA2CA9TSHR | |
| SCHEMBL1799336 | 0.79 | F2 (0.34) | PRSS1CA12CA1CA2CA9 | |
| SCHEMBL3874559 | 0.78 | NPY4R (0.36) | — | |
| SCHEMBL1804007 | 0.78 | ADAM17 (0.47) | — | |
| SCHEMBL1799060 | 0.78 | SLC9A3 (0.36) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1461313-B1 | HUMAN ADAM-10 INHIBITORS | EXELIXIS INC (US) | 2009-08-05 | — | — | EP | claimed |
| US-7951972-B2 | Human adam-10 inhibitors | EXELIXIS, INC. (US) | 2011-05-31 | — | — | US | disclosed |
| EP-1461313-B1 | HUMAN ADAM-10 INHIBITORS | EXELIXIS INC (US) | 2009-08-05 | — | — | EP | disclosed |