Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATR | Q13535 | 3/20 | 0.48 |
| ▸ | GABRA5 | P31644 | 3/20 | 0.47 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.42 |
| ▸ | GPR119 | Q8TDV5 | 3/20 | 0.41 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.39 |
| ▸ | VNN1 | O95497 | 1/20 | 0.39 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.39 |
| ▸ | FEN1 | P39748 | 1/20 | 0.39 |
| ▸ | ACHE | P22303 | 2/20 | 0.38 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.38 |
| ▸ | HTR2B | P41595 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4388608 | 0.95 | ATR (0.42) | ATRGABRA5HDAC4GPR119HRH3 | |
| SCHEMBL13690457 | 0.87 | GPR119 (0.56) | ATRGABRA5GPR119ALOX5APFEN1 | |
| SCHEMBL15539579 | 0.86 | HDAC4 (0.43) | ATRGABRA5HDAC4GPR119HRH3 | |
| SCHEMBL18849047 | 0.86 | HDAC4 (0.43) | ATRGABRA5HDAC4GPR119HRH3 | |
| SCHEMBL15539576 | 0.86 | HDAC4 (0.43) | ATRGABRA5HDAC4GPR119HRH3 | |
| SCHEMBL4056867 | 0.85 | ALOX5AP (0.42) | ATRGABRA5GPR119ALOX5APFEN1 | |
| SCHEMBL4059326 | 0.85 | PARP15 (0.45) | ATRGPR119ACHECHEK2 | |
| SCHEMBL4461701 | 0.83 | HDAC4 (0.44) | ATRGABRA5HDAC4HRH3VNN1 | |
| SCHEMBL4373471 | 0.82 | ATR (0.50) | ATRGABRA5HDAC4VNN1ALOX5AP | |
| SCHEMBL13690462 | 0.82 | GPR119 (0.57) | GPR119ALOX5APFEN1CHEK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009106561-A1 | PYRAZINE COMPOUNDS FOR TREATING GPR119 RELATED DISORDERS | BIOVITRUM AB (PUBL) (SE) | 2009-09-03 | — | — | WO | disclosed |