Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP15 | Q460N3 | 4/20 | 0.45 |
| ▸ | PARP10 | Q53GL7 | 4/20 | 0.45 |
| ▸ | PARP2 | Q9UGN5 | 2/20 | 0.45 |
| ▸ | CHEK2 | O96017 | 4/20 | 0.42 |
| ▸ | GPR119 | Q8TDV5 | 3/20 | 0.41 |
| ▸ | ACHE | P22303 | 2/20 | 0.39 |
| ▸ | MTOR | P42345 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | CDK1 | P06493 | 1/20 | 0.39 |
| ▸ | CDK2 | P24941 | 1/20 | 0.39 |
| ▸ | ATR | Q13535 | 1/20 | 0.38 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.38 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.38 |
| ▸ | LIPE | Q05469 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4056447 | 0.86 | GPR119 (0.43) | GPR119ACHEMTORATRLIPE | |
| SCHEMBL13690558 | 0.86 | GPR119 (0.58) | CHEK2GPR119 | |
| SCHEMBL4388608 | 0.85 | ATR (0.42) | CHEK2GPR119ACHEATR | |
| SCHEMBL4376173 | 0.85 | ATR (0.48) | CHEK2GPR119ACHEATR | |
| SCHEMBL4048278 | 0.83 | LIPE (0.38) | GPR119ACHELIPE | |
| SCHEMBL4055470 | 0.83 | GPR119 (0.45) | GPR119 | |
| SCHEMBL4048867 | 0.81 | SPHK2 (0.44) | GPR119ATR | |
| SCHEMBL4049899 | 0.81 | SPHK2 (0.44) | GPR119ATR | |
| SCHEMBL4456659 | 0.81 | PARP15 (0.48) | PARP15PARP10PARP2CHEK2GPR119 | |
| SCHEMBL4368582 | 0.81 | ATR (0.39) | CHEK2GPR119ACHEATRLIPE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009106561-A1 | PYRAZINE COMPOUNDS FOR TREATING GPR119 RELATED DISORDERS | BIOVITRUM AB (PUBL) (SE) | 2009-09-03 | — | — | WO | disclosed |