Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | BCHE | P06276 | 1/20 | 0.41 |
| ▸ | MMP8 | P22894 | 2/20 | 0.41 |
| ▸ | CTRB1 | P17538 | 4/20 | 0.41 |
| ▸ | BACE1 | P56817 | 2/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | KLK5 | Q9Y337 | 1/20 | 0.40 |
| ▸ | MMP9 | P14780 | 1/20 | 0.40 |
| ▸ | MMP14 | P50281 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1682692 | 0.81 | NPC1 (0.47) | NPC1RAB9ABCHECTRB1BACE1 | |
| SCHEMBL1682678 | 0.80 | NPC1 (0.46) | NPC1RAB9AMMP8CTRB1 | |
| SCHEMBL271177 | 0.79 | TRPM8 (0.47) | NPC1RAB9ABCHEBACE1 | |
| SCHEMBL23000843 | 0.79 | SMN1; SMN2 (0.47) | NPC1RAB9ACTRB1CYP1A2 | |
| SCHEMBL4582505 | 0.77 | HPGD (0.54) | NPC1RAB9AL3MBTL1LMNA | |
| SCHEMBL272596 | 0.77 | NPC1 (0.46) | NPC1RAB9ABCHECTRB1 | |
| SCHEMBL4375386 | 0.76 | ACKR3 (0.43) | NPC1RAB9AL3MBTL1LMNA | |
| SCHEMBL4382189 | 0.76 | ACKR3 (0.43) | NPC1RAB9AL3MBTL1LMNA | |
| SCHEMBL4377324 | 0.75 | PYGL (0.38) | NPC1RAB9ABCHEBACE1L3MBTL1 | |
| SCHEMBL4583485 | 0.75 | ALDH1A1 (0.47) | NPC1RAB9ABCHEL3MBTL1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2117523-A1 | INHIBITORS OF AKT ACTIVITY | SmithKline Beecham Corporation (US) | 2009-11-18 | — | — | EP | disclosed |
| EP-1968568-A2 | INHIBITORS OF Akt ACTIVITY | SmithKline Beecham Corporation (US) | 2008-09-17 | — | — | EP | disclosed |
| WO-2008098104-A1 | INHIBITORS OF AKT ACTIVITY | SMITHKLINE BEECHAM CORPORATION (US) | 2008-08-14 | — | — | WO | disclosed |
| WO-2007076423-A2 | INHIBITORS OF Akt ACTIVITY | SMITHKLINE BEECHAM CORPORATION (US) | 2007-07-05 | — | — | WO | disclosed |