Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F2 | P00734 | 3/20 | 0.37 |
| ▸ | PRSS1 | P07477 | 3/20 | 0.37 |
| ▸ | PRSS2 | P07478 | 3/20 | 0.37 |
| ▸ | PRSS3 | P35030 | 3/20 | 0.37 |
| ▸ | ST14 | Q9Y5Y6 | 3/20 | 0.37 |
| ▸ | F10 | P00742 | 2/20 | 0.37 |
| ▸ | LTA4H | P09960 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | MLNR | O43193 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | HSPB1 | P04792 | 1/20 | 0.34 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.34 |
| ▸ | MMP1 | P03956 | 1/20 | 0.34 |
| ▸ | MMP2 | P08253 | 1/20 | 0.34 |
| ▸ | MMP13 | P45452 | 1/20 | 0.34 |
| ▸ | MMP14 | P50281 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1798846 | 0.91 | DAGLA (0.38) | LTA4HALDH1A1ADAMTS4MMP1MMP2 | |
| SCHEMBL4377327 | 0.89 | F2 (0.39) | F2PRSS1PRSS2PRSS3ST14 | |
| SCHEMBL4370906 | 0.83 | SCN9A (0.36) | F2PRSS1PRSS2PRSS3ST14 | |
| SCHEMBL1799336 | 0.83 | F2 (0.34) | F2PRSS1PRSS2PRSS3ST14 | |
| SCHEMBL4375791 | 0.81 | MMP2 (0.42) | LTA4HMMP1MMP2MMP13MMP14 | |
| SCHEMBL4372704 | 0.79 | HPGDS (0.41) | MLNRSCN9A | |
| SCHEMBL1800831 | 0.78 | ADAM17 (0.50) | ADAMTS4MMP1MMP2MMP13MMP14 | |
| SCHEMBL3874559 | 0.77 | NPY4R (0.36) | — | |
| SCHEMBL4375795 | 0.77 | TBXA2R (0.34) | PRSS1SCN9AFPR2 | |
| SCHEMBL4371687 | 0.77 | SMN1; SMN2 (0.36) | PRSS1LTA4HMMP2MMP13MMP14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1461313-B1 | HUMAN ADAM-10 INHIBITORS | EXELIXIS INC (US) | 2009-08-05 | — | — | EP | claimed |
| US-7951972-B2 | Human adam-10 inhibitors | EXELIXIS, INC. (US) | 2011-05-31 | — | — | US | disclosed |
| EP-1461313-B1 | HUMAN ADAM-10 INHIBITORS | EXELIXIS INC (US) | 2009-08-05 | — | — | EP | disclosed |