Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLA2G2A | P14555 | 2/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 4/20 | 0.45 |
| ▸ | F2RL3 | Q96RI0 | 2/20 | 0.43 |
| ▸ | PTGER3 | P43115 | 1/20 | 0.42 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.42 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 4/20 | 0.41 |
| ▸ | BRD4 | O60885 | 1/20 | 0.40 |
| ▸ | CASR | P41180 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15062678 | 0.86 | PLA2G2A (0.43) | PLA2G2AMEN1KMT2AMAPTTHRB | |
| SCHEMBL8360274 | 0.84 | ALDH1A1 (0.52) | PLA2G2AKMT2AMAPTTP53POLB | |
| SCHEMBL4541878 | 0.81 | ALDH1A1 (0.53) | PLA2G2AMEN1KMT2AMAPTPOLB | |
| SCHEMBL4375652 | 0.81 | ALDH1A1 (0.50) | PLA2G2AMEN1KMT2AMAPTTP53 | |
| SCHEMBL27789954 | 0.76 | CCR2 (0.52) | PLA2G2AMEN1KMT2AMAPTTP53 | |
| SCHEMBL4381044 | 0.75 | MAPT (0.43) | PLA2G2AMEN1KMT2AMAPTTP53 | |
| SCHEMBL3088631 | 0.73 | P2RX4 (0.54) | MEN1KMT2AMAPTTP53POLB | |
| SCHEMBL11461389 | 0.73 | PLA2G2A (0.58) | PLA2G2AMEN1KMT2AMAPTPTGER3 | |
| SCHEMBL2071948 | 0.73 | GABRA1 (0.54) | MEN1KMT2AMAPTBRD4POLB | |
| SCHEMBL8356890 | 0.72 | PLA2G2A (0.52) | PLA2G2AMEN1KMT2AMAPTOPRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2049520-A2 | INDOLE COMPOUNDS | Ironwood Pharmaceuticals, Inc. (US) | 2009-04-22 | — | — | EP | disclosed |
| WO-2008019357-A2 | INDOLE COMPOUNDS | IRONWOOD PHARMACEUTICALS, INC. (US) | 2008-02-14 | — | — | WO | disclosed |