Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 7/20 | 0.50 |
| ▸ | HTT | P42858 | 2/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | BCHE | P06276 | 2/20 | 0.47 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.46 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4379039 | 0.84 | ACHE (0.53) | ACHEHTTGAAMAPTBCHE | |
| SCHEMBL4560546 | 0.84 | HTT (0.43) | ACHEHTTGAAMAPTBCHE | |
| SCHEMBL3798774 | 0.79 | HTT (0.55) | ACHEHTTGAAMAPTBCHE | |
| SCHEMBL10061487 | 0.75 | HTT (0.67) | ACHEHTTGAAMAPTBCHE | |
| SCHEMBL9208663 | 0.73 | HTT (0.74) | ACHEHTTGAAMAPTBCHE | |
| SCHEMBL9749208 | 0.72 | HTT (0.64) | ACHEHTTGAAMAPTBCHE | |
| SCHEMBL4560545 | 0.72 | CHEK1 (0.51) | ACHEHTTGAAMAPTBCHE | |
| SCHEMBL8473136 | 0.72 | HTT (0.69) | ACHEHTTGAAMAPTBCHE | |
| SCHEMBL8472225 | 0.71 | HTT (0.71) | ACHEHTTGAAMAPTBCHE | |
| SCHEMBL8476129 | 0.70 | HTT (0.73) | ACHEHTTGAAMAPTBCHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2091943-A2 | HETEROCYCLIC COMPOUNDS AND THEIR USE AS GLYCOGEN SYNTHASE KINASE 3 INHIBITORS | Abbott GmbH & Co. KG (DE) | 2009-08-26 | — | — | EP | disclosed |
| WO-2008046919-A2 | HETEROCYCLIC COMPOUNDS AND THEIR USE AS GLYCOGEN SYNTHASE KINASE 3 INHIBITORS | ABBOTT GMBH & CO. KG (DE) | 2008-04-24 | — | — | WO | disclosed |