Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | GSK3B | P49841 | 8/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | GPR6 | P46095 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4386485 | 0.90 | HSD11B1 (0.51) | RAB9AKMT2AMEN1ALDH1A1L3MBTL1 | |
| SCHEMBL4385766 | 0.87 | RAB9A (0.51) | RAB9AKMT2AMEN1ALDH1A1L3MBTL1 | |
| SCHEMBL4380168 | 0.87 | GSK3B (0.38) | GSK3BCYP2D6 | |
| SCHEMBL4378646 | 0.86 | MEN1 (0.46) | KMT2AMEN1L3MBTL1GSK3BGPR6 | |
| SCHEMBL2066088 | 0.85 | GSK3B (0.40) | RAB9AALDH1A1GSK3BKDM4ELMNA | |
| SCHEMBL4379543 | 0.84 | CYP1A2 (0.38) | KMT2AMEN1GSK3BCYP2D6 | |
| SCHEMBL4377879 | 0.84 | MEN1 (0.45) | KMT2AMEN1L3MBTL1GSK3BGPR6 | |
| SCHEMBL2065359 | 0.84 | GSK3B (0.46) | KMT2AMEN1GSK3BLMNACYP2D6 | |
| SCHEMBL2065745 | 0.82 | KDM4E (0.40) | RAB9AALDH1A1GSK3BKDM4ELMNA | |
| SCHEMBL2065304 | 0.82 | GSK3B (0.40) | GSK3BCYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2121635-A2 | SUBSTITUTED HETEROARYL PYRIDOPYRIMIDONE DERIVATIVES | Sanofi-Aventis (FR) | 2009-11-25 | — | — | EP | claimed |
| WO-2008078196-A2 | SUBSTITUTED HETEROARYL PYRIDOPYRIMIDONE DERIVATIVES | SANOFI-AVENTIS (FR) | 2008-07-03 | — | — | WO | claimed |
| EP-1939187-A1 | Substituted heteroaryl pyridopyrimidone derivatives | Sanofi-Aventis (FR) | 2008-07-02 | — | — | EP | claimed |
| EP-2121635-A2 | SUBSTITUTED HETEROARYL PYRIDOPYRIMIDONE DERIVATIVES | Sanofi-Aventis (FR) | 2009-11-25 | — | — | EP | disclosed |
| WO-2008078196-A2 | SUBSTITUTED HETEROARYL PYRIDOPYRIMIDONE DERIVATIVES | SANOFI-AVENTIS (FR) | 2008-07-03 | — | — | WO | disclosed |
| EP-1939187-A1 | Substituted heteroaryl pyridopyrimidone derivatives | Sanofi-Aventis (FR) | 2008-07-02 | — | — | EP | disclosed |