Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.51 |
| ▸ | ALPL | P05186 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | CRHBP | P24387 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.44 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | CASP1 | P29466 | 1/20 | 0.42 |
| ▸ | MARS1 | P56192 | 1/20 | 0.41 |
| ▸ | EIF4E | P06730 | 1/20 | 0.40 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.40 |
| ▸ | PRKCG | P05129 | 1/20 | 0.40 |
| ▸ | PRKCB | P05771 | 1/20 | 0.40 |
| ▸ | IL1R1 | P14778 | 1/20 | 0.40 |
| ▸ | PRKCA | P17252 | 1/20 | 0.40 |
| ▸ | TNFRSF1A | P19438 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9585956 | 0.88 | KDM4E (0.51) | KDM4ESMN1; SMN2NPC1CRHBPRAB9A | |
| SCHEMBL13398672 | 0.84 | KDM4E (0.50) | KDM4EALDH1A1TP53EIF4EDHODH | |
| SCHEMBL4371383 | 0.83 | ALPL (0.49) | KDM4EALPLSMN1; SMN2NPC1RAB9A | |
| SCHEMBL13398544 | 0.81 | KDM4E (0.63) | KDM4EALPLSMN1; SMN2NPC1RAB9A | |
| SCHEMBL9587747 | 0.81 | CNR1 (0.43) | ALPLPRKD3PRKCGPRKCBIL1R1 | |
| SCHEMBL9587799 | 0.80 | MAPT (0.53) | KDM4ESMN1; SMN2NPC1RAB9ATSHR | |
| SCHEMBL10432896 | 0.78 | SMN1; SMN2 (0.39) | KDM4EALPLSMN1; SMN2NPC1CRHBP | |
| Hydrochloric Acid SCHEMBL9586015 | 0.77 | PMP22 (0.56) | ALPLTSHRTDP1 | |
| SCHEMBL9585511 | 0.76 | KDM4E (0.55) | KDM4ETSHREIF4ETLR7GRM1 | |
| SCHEMBL4373610 | 0.76 | RORB (0.46) | KDM4EALPLSMN1; SMN2NPC1CRHBP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009117421-A2 | HETEROCYCLIC MODULATORS OF GPR119 FOR TREATMENT OF DISEASE | KALYPSYS, INC. (US) | 2009-09-24 | — | — | WO | disclosed |
| WO-2009117421-A2 | HETEROCYCLIC MODULATORS OF GPR119 FOR TREATMENT OF DISEASE | KALYPSYS, INC. (US) | 2009-09-24 | — | — | WO | disclosed |
| US-5204482-A | Ethylenediamine monoamide heteroaryl derivatives | HOFFMAN-LAROCHE INC. (US) | 1993-04-20 | — | — | US | disclosed |
| US-5011849-A | Monoamine oxidase inhibitors | HOFFMANN-LA ROCHE INC. (US) | 1991-04-30 | — | — | US | disclosed |
| EP-0352581-A2 | Ethylene diaminmonoamide derivatives | F. HOFFMANN-LA ROCHE AG (CH) | 1990-01-31 | — | — | EP | disclosed |