Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALPL | P05186 | 1/20 | 0.49 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.45 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 5/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | PKM | P14618 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | CNR1 | P21554 | 2/20 | 0.41 |
| ▸ | MRGPRX4 | Q96LA9 | 2/20 | 0.41 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.40 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 3/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9587799 | 0.86 | MAPT (0.53) | MAPTPOLBKDM4ESMN1; SMN2RAB9A | |
| SCHEMBL4380087 | 0.83 | KDM4E (0.51) | ALPLMAPTKDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL4371693 | 0.78 | ALPL (0.49) | ALPLSLC6A3MAPTPOLBKDM4E | |
| SCHEMBL983944 | 0.78 | SLC6A3 (0.47) | SLC6A3KDM4ECYP1A2CYP3A4 | |
| SCHEMBL4380144 | 0.76 | KDM4E (0.68) | ALPLS1PR4SLC6A3MAPTPOLB | |
| SCHEMBL9587747 | 0.76 | CNR1 (0.43) | ALPLMAPTPOLBL3MBTL1CNR1 | |
| SCHEMBL9588826 | 0.75 | MAPT (0.45) | MAPTPOLBKDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL10432896 | 0.74 | SMN1; SMN2 (0.39) | ALPLMAPTPOLBKDM4EALDH1A1 | |
| SCHEMBL23538248 | 0.72 | NPSR1 (0.46) | S1PR4MAPTPOLBKDM4EALDH1A1 | |
| SCHEMBL24984506 | 0.72 | ALPL (0.58) | ALPLS1PR4SLC6A3MAPTPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009117421-A2 | HETEROCYCLIC MODULATORS OF GPR119 FOR TREATMENT OF DISEASE | KALYPSYS, INC. (US) | 2009-09-24 | — | — | WO | disclosed |
| WO-2009117421-A2 | HETEROCYCLIC MODULATORS OF GPR119 FOR TREATMENT OF DISEASE | KALYPSYS, INC. (US) | 2009-09-24 | — | — | WO | disclosed |