Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.53 |
| ▸ | NPC1 | O15118 | 2/20 | 0.48 |
| ▸ | TSHR | P16473 | 2/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
| ▸ | CDC7 | O00311 | 1/20 | 0.47 |
| ▸ | DBF4 | Q9UBU7 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.43 |
| ▸ | GABRA2 | P47869 | 5/20 | 0.43 |
| ▸ | GABRB2 | P47870 | 5/20 | 0.43 |
| ▸ | DPP4 | P27487 | 1/20 | 0.42 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.42 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9588826 | 0.90 | MAPT (0.45) | MAPTKDM4ENPC1TSHRPOLB | |
| SCHEMBL13398594 | 0.86 | GABRG2 (0.43) | MAPTKDM4ENPC1RAB9AMAPK1 | |
| SCHEMBL4371383 | 0.86 | ALPL (0.49) | MAPTKDM4ENPC1POLBRAB9A | |
| SCHEMBL9586819 | 0.85 | GRM6 (0.54) | MAPTKDM4ENPC1RAB9ACDC7 | |
| SCHEMBL9587129 | 0.82 | TARBP2 (0.53) | MAPTKDM4ENPC1POLBRAB9A | |
| SCHEMBL4373661 | 0.80 | MAPT (0.53) | MAPTKDM4ENPC1TSHRPOLB | |
| SCHEMBL9585878 | 0.80 | TRPM8 (0.53) | MAPTKDM4EGABRA2GABRB2 | |
| SCHEMBL9586307 | 0.80 | CDC7 (0.47) | MAPTKDM4ENPC1TSHRRAB9A | |
| SCHEMBL4380087 | 0.80 | KDM4E (0.51) | MAPTKDM4ENPC1TSHRRAB9A | |
| SCHEMBL9586344 | 0.79 | L3MBTL1 (0.46) | MAPTKDM4ENPC1RAB9AHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5204482-A | Ethylenediamine monoamide heteroaryl derivatives | HOFFMAN-LAROCHE INC. (US) | 1993-04-20 | — | — | US | disclosed |
| US-5011849-A | Monoamine oxidase inhibitors | HOFFMANN-LA ROCHE INC. (US) | 1991-04-30 | — | — | US | disclosed |