Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB2 | P07550 | 1/20 | 0.40 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.40 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.40 |
| ▸ | BLM | P54132 | 1/20 | 0.39 |
| ▸ | CTSA | P10619 | 3/20 | 0.38 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | CXCL8 | P10145 | 3/20 | 0.37 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.36 |
| ▸ | CTSG | P08311 | 1/20 | 0.36 |
| ▸ | CTRB1 | P17538 | 1/20 | 0.36 |
| ▸ | CMA1 | P23946 | 1/20 | 0.36 |
| ▸ | CASP1 | P29466 | 1/20 | 0.36 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.36 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.36 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | ACP3 | P15309 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4584586 | 0.82 | GAA (0.46) | HIF1ACTSAKMT2A | |
| SCHEMBL4387389 | 0.80 | CNR2 (0.46) | CTSAACP3 | |
| SCHEMBL4371317 | 0.80 | ALDH1A1 (0.48) | — | |
| SCHEMBL4377187 | 0.80 | DPP4 (0.43) | KMT2ACTRB1L3MBTL1 | |
| SCHEMBL4373941 | 0.80 | DPP4 (0.43) | KMT2ACTRB1L3MBTL1 | |
| SCHEMBL4380602 | 0.76 | PRCP (0.41) | ADRB2CYP2D6NFKB1BLMKMT2A | |
| SCHEMBL4371128 | 0.74 | TRPM8 (0.41) | BLMKMT2AACP3 | |
| SCHEMBL11244690 | 0.73 | CXCL8 (0.44) | ADRB2ADRB1HIF1ACTSAAOC3 | |
| SCHEMBL4596289 | 0.71 | ADRB2 (0.51) | ADRB2ADRB1CYP2D6NFKB1HIF1A | |
| SCHEMBL4584032 | 0.71 | HDAC4 (0.43) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2117523-A1 | INHIBITORS OF AKT ACTIVITY | SmithKline Beecham Corporation (US) | 2009-11-18 | — | — | EP | disclosed |
| WO-2008098104-A1 | INHIBITORS OF AKT ACTIVITY | SMITHKLINE BEECHAM CORPORATION (US) | 2008-08-14 | — | — | WO | disclosed |