SCHEMBL4381990

SCHEMBL4381990

O=C1C2=C(CCCC2)C(=O)N1Cc1cccc(-n2nc3ccccc3n2)c1O

nearest known ligand 0.40

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
LMNA P02545 3/20 0.40
KDM4E B2RXH2 1/20 0.40
CYP1A2 P05177 1/20 0.36
CYP2C9 P11712 1/20 0.36
CYP2C19 P33261 1/20 0.36
NPC1 O15118 2/20 0.33
RAB9A P51151 2/20 0.33
POLB P06746 3/20 0.33
MEN1 O00255 2/20 0.32
KMT2A Q03164 2/20 0.32
SMN1; SMN2 Q16637 1/20 0.31
TSHR P16473 1/20 0.31
ALDH1A1 P00352 1/20 0.31
GSK3B P49841 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL25211582 0.88 LMNA (0.36) LMNAKDM4ECYP1A2CYP2C9CYP2C19
SCHEMBL23222483 0.86 LMNA (0.39) LMNAKDM4ECYP1A2CYP2C9CYP2C19
SCHEMBL272931 0.84 NPC1 (0.49) LMNAKDM4ECYP1A2CYP2C9CYP2C19
SCHEMBL29353331 0.84 NPC1 (0.49) LMNAKDM4ECYP1A2CYP2C9CYP2C19
SCHEMBL2538971 0.82 NPC1 (0.40) LMNAKDM4ECYP1A2CYP2C9CYP2C19
SCHEMBL29403943 0.82 NPC1 (0.40) LMNAKDM4ECYP1A2CYP2C9CYP2C19
SCHEMBL28879537 0.82 LMNA (0.38) LMNAKDM4ENPC1RAB9APOLB
SCHEMBL25267640 0.80 NPC1 (0.36) LMNAKDM4ENPC1RAB9APOLB
SCHEMBL30097874 0.80 NPC1 (0.40) LMNAKDM4ENPC1RAB9APOLB
SCHEMBL8588338 0.78 ALDH1A1 (0.40) LMNAKDM4ECYP2C9NPC1RAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 26 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1116751-B1 POLYCARBONATE RESIN COMPOSITION, OPTICAL RECORDING MEDIUM, AND SUBSTRATE THEREFOR TEIJIN LTD (JP) 2009-07-29 EP disclosed
CN-1250646-C Polycarbonate resin composition, optical recording medium, and substrate therefor TEIJIN LTD (JP) 2006-04-12 CN disclosed
CN-1249120-C Aromatic polycarbonate, process for producing the same, and composition containing the same TEIJIN LTD (JP) 2006-04-05 CN disclosed
EP-1191064-B1 AROMATIC POLYCARBONATE COMPOSITION TEIJIN LTD (JP) 2005-12-07 EP disclosed
CN-1175047-C Aromatic polycarbonate composition ������������ʽ���� 2004-11-10 CN disclosed
US-20040198884-A1 Polycarbonate composition with excellent releasability from mold TEIJIN LIMITED (JP) 2004-10-07 US disclosed
US-20040147655-A1 Aromatic polycarbonate resin composition TEIJIN LIMITED (JP) 2004-07-29 US disclosed
EP-1120435-B1 APPARATUS AND METHOD FOR PRODUCING RESIN TEIJIN LTD (JP) 2004-05-06 EP disclosed
US-20040034130-A1 An aromatic polycarbonate (obtained by reacting an aromatic dihydroxy compound with a carbonic acid diester) using an ester exchange catalyst selected form alkali or alkaline metal compound; an epoxy compound; and an aromatic compound TEIJIN LIMITED (JP) 2004-02-19 US disclosed
EP-1316576-A1 PROCESS FOR PREPARATION OF MOLTEN MIXTURES OF AROMATIC HYDROXYL COMPOUNDS AND CARBONIC DIESTERS TEIJIN LIMITED (JP) 2003-06-04 EP disclosed
US-6448365-B1 Aromatic polycarbonate composition TEIJIN LIMITED (JP) 2002-09-10 US disclosed
US-6423813-B1 FROM PHENOLIC COMPOUNDS TEIJIN LIMITED (JP) 2002-07-23 US disclosed
US-6407199-B1 MIXTURE OF AROMATIC POLYCARBONATE AND CYCLIC CARBONATE COMPOUND; HEAT RESISTANCE TEIJIN LIMITED (JP) 2002-06-18 US disclosed
CN-1351632-A Aromatic polycarbonate composition TEIJIN LTD (JP) 2002-05-29 CN disclosed
EP-1191064-A1 AROMATIC POLYCARBONATE COMPOSITION TEIJIN LIMITED (JP) 2002-03-27 EP disclosed
EP-1179556-A1 BRANCHED AROMATIC POLYCARBONATE, PROCESS FOR PRODUCING THE SAME, AND BLOW-MOLDED ARTICLE THEREOF TEIJIN LIMITED (JP) 2002-02-13 EP disclosed
CN-1319123-A Polycarbonate resin composition, optical recording medium, and substrate therefor TEIJIN LTD (JP) 2001-10-24 CN disclosed
EP-1120435-A1 APPARATUS AND METHOD FOR PRODUCING RESIN TEIJIN LIMITED (JP) 2001-08-01 EP disclosed
EP-1116751-A1 POLYCARBONATE RESIN COMPOSITION, OPTICAL RECORDING MEDIUM, AND SUBSTRATE THEREFOR TEIJIN LIMITED (JP) 2001-07-18 EP disclosed
EP-0992522-A1 CARBONIC DIESTER, AROMATIC POLYCARBONATE, PRODUCTION APPARATUS, AND PROCESS FOR PRODUCTION TEIJIN LIMITED (JP) 2000-04-12 EP disclosed