Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4384964 | 0.89 | CYP17A1 (0.36) | PPARGKCNH2MEN1KMT2AHRH3 | |
| SCHEMBL7988365 | 0.89 | MEN1 (0.48) | PPARGKCNH2MEN1KMT2AHRH3 | |
| SCHEMBL4379596 | 0.85 | ALDH1A1 (0.49) | KCNH2MEN1KMT2ASMN1; SMN2LMNA | |
| SCHEMBL4379134 | 0.82 | HRH3 (0.39) | HRH3SMN1; SMN2MAPK1 | |
| SCHEMBL4389358 | 0.82 | HRH3 (0.50) | KCNH2HRH3 | |
| Oxalic Acid SCHEMBL7991342 | 0.81 | LMNA (0.54) | MEN1KMT2ASMN1; SMN2LMNA | |
| SCHEMBL7987297 | 0.81 | HRH3 (0.54) | KCNH2MEN1KMT2AHRH3SMN1; SMN2 | |
| SCHEMBL4380966 | 0.81 | NQO1 (0.45) | KCNH2MEN1KMT2AHRH3SMN1; SMN2 | |
| SCHEMBL4392013 | 0.80 | HRH3 (0.43) | HRH3MAPK1 | |
| SCHEMBL7976959 | 0.79 | ITGB3 (0.36) | PPARGKCNH2HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6248765-B1 | ANTIINFLAMMATORY AGENTS; HYPOTENSIVE AGENTS | INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICAL (FR) | 2001-06-19 | — | — | US | claimed |
| EP-0760811-A1 | IMIDAZOLE DERIVATIVES AS HISTAMINE RECEPTOR H 3? (ANT)AGONISTS | INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) (FR) | 1997-03-12 | — | — | EP | claimed |
| WO-1996029315-A2 | IMIDAZOLE DERIVATIVES AS HISTAMINE RECEPTOR H3 (ANT)AGONISTS | INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (FR) | 1996-09-26 | — | — | WO | claimed |
| EP-0760811-B1 | IMIDAZOLE DERIVATIVES AS HISTAMINE RECEPTOR H3 MODULATORS | INST NAT SANTE RECH MED (FR) | 2009-11-18 | — | — | EP | disclosed |
| US-6248765-B1 | ANTIINFLAMMATORY AGENTS; HYPOTENSIVE AGENTS | INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICAL (FR) | 2001-06-19 | — | — | US | disclosed |
| WO-1996030048-A1 | PROTEIN KINASE C INHIBITORS | ELI LILLY AND COMPANY (US) | 1996-10-03 | — | — | WO | disclosed |
| WO-1996029315-A2 | IMIDAZOLE DERIVATIVES AS HISTAMINE RECEPTOR H3 (ANT)AGONISTS | INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (FR) | 1996-09-26 | — | — | WO | disclosed |