Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FFAR1 | O14842 | 9/20 | 0.54 |
| ▸ | MGLL | Q99685 | 1/20 | 0.51 |
| ▸ | FFAR4 | Q5NUL3 | 4/20 | 0.48 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.44 |
| ▸ | CA1 | P00915 | 1/20 | 0.43 |
| ▸ | CA2 | P00918 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | PLAAT3 | P53816 | 1/20 | 0.43 |
| ▸ | PLAAT5 | Q96KN8 | 1/20 | 0.43 |
| ▸ | PLAAT2 | Q9NWW9 | 1/20 | 0.43 |
| ▸ | PLAAT4 | Q9UL19 | 1/20 | 0.43 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.43 |
| ▸ | IDO1 | P14902 | 1/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.42 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.42 |
| ▸ | PPARD | Q03181 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL117230 | 0.82 | FFAR1 (0.73) | FFAR1FFAR4PDPK1PLAAT3PLAAT5 | |
| SCHEMBL363489 | 0.81 | FFAR1 (0.61) | FFAR1FFAR4CA1CA2TRPV1 | |
| Trifluoroacetic Acid SCHEMBL27529274 | 0.79 | FFAR1 (0.61) | FFAR1FFAR4PDPK1CA1CA2 | |
| SCHEMBL5455 | 0.77 | FFAR1 (0.71) | FFAR1FFAR4PDPK1CA1CA2 | |
| Hydrochloric Acid SCHEMBL6440989 | 0.75 | FFAR1 (0.69) | FFAR1FFAR4PDPK1CA1CA2 | |
| SCHEMBL1454387 | 0.73 | FFAR1 (0.60) | FFAR1PDPK1PLAAT3PLAAT5PLAAT2 | |
| SCHEMBL5867429 | 0.73 | MGLL (0.59) | MGLLCA1CA2TSHRHDAC1 | |
| SCHEMBL30357702 | 0.72 | FFAR1 (0.60) | FFAR1FFAR4PDPK1PLAAT3PLAAT5 | |
| SCHEMBL4179 | 0.72 | MGLL (1.00) | MGLLCA1CA2TSHR | |
| SCHEMBL30990549 | 0.71 | FFAR1 (0.59) | FFAR1FFAR4PDPK1CA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1686119-B1 | Pyrimidine-5-one derivatives as LDL-PLA2 inhibitors | SMITHKLINE BEECHAM PLC (GB) | 2009-07-29 | — | — | EP | disclosed |
| EP-1686119-A1 | PYRIMIDINE-4-ONE DERIVATIVES AS LDL-PLA2 INHIBITORS | SMITHKLINE BEECHAM PLC (GB) | 2006-08-02 | — | — | EP | disclosed |
| EP-1263740-B1 | PYRIMIDINE-4-ONE DERIVATIVE AS LDL-PLA2 INHIBITOR | SMITHKLINE BEECHAM PLC (GB) | 2006-07-19 | — | — | EP | disclosed |