SCHEMBL5455

SCHEMBL5455

O=C(O)CCc1ccc(Br)cc1

nearest known ligand 0.71

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
FFAR1 O14842 12/20 0.71
FFAR4 Q5NUL3 5/20 0.71
KEAP1 Q14145 1/20 0.64
IDO1 P14902 1/20 0.59
PPARD Q03181 1/20 0.58
CA1 P00915 1/20 0.55
CA2 P00918 1/20 0.55
PDPK1 O15530 1/20 0.54
ALDH1A1 P00352 1/20 0.51
MAPT P10636 1/20 0.51
PKM P14618 1/20 0.51
HPGD P15428 1/20 0.51
TSHR P16473 1/20 0.51
PPARG P37231 1/20 0.51
NCOA2 Q15596 1/20 0.51
NPSR1 Q6W5P4 1/20 0.51
HSD17B10 Q99714 1/20 0.51
RXFP1 Q9HBX9 1/20 0.51
NCOR2 Q9Y618 1/20 0.51

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL6440989 0.98 FFAR1 (0.69) FFAR1FFAR4KEAP1IDO1PPARD
Trifluoroacetic Acid SCHEMBL27529274 0.90 FFAR1 (0.61) FFAR1FFAR4KEAP1IDO1PPARD
SCHEMBL30990549 0.89 FFAR1 (0.59) FFAR1FFAR4KEAP1IDO1PPARD
SCHEMBL69746 0.88 FFAR1 (0.81) FFAR1FFAR4KEAP1CA1CA2
SCHEMBL1857558 0.87 HDAC1 (0.67) FFAR1FFAR4IDO1ALDH1A1MAPT
SCHEMBL29018552 0.86 FFAR1 (0.59) FFAR1FFAR4KEAP1IDO1PPARD
SCHEMBL29018554 0.86 FFAR1 (0.59) FFAR1FFAR4KEAP1IDO1PPARD
Hydrochloric Acid SCHEMBL25264643 0.85 FFAR1 (0.77) FFAR1FFAR4KEAP1CA1CA2
SCHEMBL1114650 0.85 MAPT (0.66) FFAR1FFAR4MAPTHSD17B10RXFP1
Hydrochloric Acid SCHEMBL3866368 0.85 SMN1; SMN2 (0.64) FFAR1FFAR4IDO1ALDH1A1MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 753 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-120137643-A Composite material, preparation method thereof, photoelectric device and display device 广东聚华新型显示研究院 2025-06-13 CN claimed
US-12304894-B2 Derivatives of adamantyl oxadiazoles and pharmaceutically acceptable solvates, hydrates and salts thereof, pharmaceutical composition comprising same, synthesis method, suitable for use as effective and selective inhibitors of the reductase activity of the enzyme 11-beta dehydrogenase type 1 (11β-HSD1) PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE (CL) 2025-05-20 US claimed
CN-118496175-A TRADD inhibitor derivative and preparation method and application thereof 安徽医科大学 2024-08-16 CN claimed
US-20220194909-A1 DERIVATIVES OF ADAMANTYL OXADIAZOLES AND PHARMACEUTICALLY ACCEPTABLE SOLVATES, HYDRATES AND SALTS THEREOF, PHARMACEUTICAL COMPOSITION COMPRISING SAME, SYNTHESIS METHOD, SUITABLE FOR USE AS EFFECTIVE AND SELECTIVE INHIBITORS OF THE REDUCTASE ACTIVITY OF THE ENZYME 11-BETA DEHYDROGENASE TYPE 1 (11B-HSD1) PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE (CL) 2022-06-23 US claimed
WO-2020210922-A1 DERIVATIVES OF ADAMANTYL OXADIAZOLES AND PHARMACEUTICALLY ACCEPTABLE SOLVATES, HYDRATES AND SALTS THEREOF, PHARMACEUTICAL COMPOSITION COMPRISING SAME, SYNTHESIS METHOD, SUITABLE FOR USE AS EFFECTIVE AND SELECTIVE INHIBITORS OF THE REDUCTASE ACTIVITY OF THE ENZYME 11-BETA DEHYDROGENASE TYPE 1 (11Β-HSD1) PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE (CL) 2020-10-22 WO claimed
US-20170101440-A1 METHODS OF TREATING OPHTHALMIC DISEASES USING NPR-B AGONISTS TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2017-04-13 US claimed
CN-1201454-A Meta-guanidino, ureido, thioureido or azacyclic aminobenzoic acid derivatives as integrin antagonists SEARLE & CO (US) 1998-12-09 CN claimed
CN-122054798-A Perovskite absorption layer, perovskite/silicon laminated solar cell and preparation method thereof 宣城先进光伏技术有限公司 2026-05-15 CN disclosed
EP-4709725-A1 HETEROCYCLIC COMPOUNDS AND USES THEREOF Progentos Therapeutics, Inc. (US) 2026-03-18 EP disclosed
US-12404265-B2 Substituted pyridine derivatives as SARM1 inhibitors NURA BIO, INC. (US) 2025-09-02 US disclosed
WO-2025128805-A1 A CYCLIC PEPTIDE IL-1BETA TRAP FOR THE TREATMENT OF ATHEROSCLEROSIS AND INFLAMMATORY DISORDERS MERCK SHARP & DOHME LLC (US) 2025-06-19 WO disclosed
CN-120137643-A Composite material, preparation method thereof, photoelectric device and display device 广东聚华新型显示研究院 2025-06-13 CN disclosed
US-12304894-B2 Derivatives of adamantyl oxadiazoles and pharmaceutically acceptable solvates, hydrates and salts thereof, pharmaceutical composition comprising same, synthesis method, suitable for use as effective and selective inhibitors of the reductase activity of the enzyme 11-beta dehydrogenase type 1 (11β-HSD1) PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE (CL) 2025-05-20 US disclosed
US-4885153-A Radiohalogenated for proteins NEORX CORPORATION (US) 1989-12-05 US disclosed
US-RE32944-E Aromatic carboxylic amide derivatives Kissei Yakuhin Kogyo Kabushiki (JP) 1989-06-06 US disclosed
CN-86108331-A The halogenated radioactive small molecule of labelled protein 1987-11-04 CN disclosed
EP-0203764-A2 Radiohalogenated small molecules for protein labeling NEORX CORPORATION (US) 1986-12-03 EP disclosed
US-4070484-A Antiallergic composition containing aromatic carboxylic amide derivatives and method of using the same KISSEI PHARMACEUTICAL CO., LTD. (JA) 1978-01-24 US disclosed
US-4026896-A ANTIALLERGENS KISSEI YAKUHIN KOGYO KABUSHIKI KAISHA (KISSEI PHARMACEUTICAL CO. LTD.) (JA) 1977-05-31 US disclosed
US-3940422-A ANTIALLERGEN KISSEI YAKUHIN KOGYO KABUSHIKI KAISHA (JA) 1976-02-24 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12404265-B2 Substituted pyridine derivatives as SARM1 inhibitors SARM1, SARNP, ADRM1 FFAR1 4246/4885FFAR4 4580/4885KEAP1 534/4885
US-20220194909-A1 DERIVATIVES OF ADAMANTYL OXADIAZOLES AND PHARMACEUTICALLY ACCEPTABLE SOLVATES, HYDRATES AND SALTS THEREOF, PHARMACEUTICAL COMPOSITION COMPRISING SAME, SYNTHESIS METHOD, SUITABLE FOR USE AS EFFECTIVE AND SELECTIVE INHIBITORS OF THE REDUCTASE ACTIVITY OF THE ENZYME 11-BETA DEHYDROGENASE TYPE 1 (11B-HSD1) HSD11B1, HSD11B2, CYP11B1 FFAR1 695/4885FFAR4 1638/4885KEAP1 1504/4885
US-20170101440-A1 METHODS OF TREATING OPHTHALMIC DISEASES USING NPR-B AGONISTS NPR1, EDNRB, NPR3 FFAR1 79/4885FFAR4 119/4885KEAP1 3721/4885
US-12304894-B2 Derivatives of adamantyl oxadiazoles and pharmaceutically acceptable solvates, hydrates and salts thereof, pharmaceutical composition comprising same, synthesis method, suitable for use as effective and selective inhibitors of the reductase activity of the enzyme 11-beta dehydrogenase type 1 (11β-HSD1) HSD11B1, HSD11B2, HSD17B1 FFAR1 623/4885FFAR4 1493/4885KEAP1 1272/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.