Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 2/20 | 0.45 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 3/20 | 0.44 |
| ▸ | BLM | P54132 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 4/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | TPSAB1 | Q15661 | 1/20 | 0.40 |
| ▸ | MIF | P14174 | 1/20 | 0.40 |
| ▸ | F2 | P00734 | 2/20 | 0.40 |
| ▸ | F7 | P08709 | 2/20 | 0.40 |
| ▸ | F10 | P00742 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4059253 | 0.83 | NAMPT (0.61) | NAMPTPOLBTP53MAPTMEN1 | |
| SCHEMBL7656460 | 0.75 | POLB (0.60) | HDAC1POLBBLMTP53MAPT | |
| SCHEMBL2839499 | 0.75 | ITGB3 (0.52) | NAMPTHDAC1POLBBLMMAPT | |
| SCHEMBL2837835 | 0.75 | NAMPT (0.48) | NAMPTHDAC1TP53MAPTMEN1 | |
| SCHEMBL2841991 | 0.74 | LMNA (0.49) | NAMPTMEN1KMT2AALDH1A1 | |
| SCHEMBL2833516 | 0.73 | NAMPT (0.42) | NAMPTHDAC1POLBBLMTP53 | |
| SCHEMBL2832025 | 0.72 | NAMPT (0.49) | NAMPTMAPTMEN1KMT2AF2 | |
| SCHEMBL4374052 | 0.71 | LMNA (0.45) | POLBMAPTMEN1KMT2AALDH1A1 | |
| SCHEMBL2842036 | 0.71 | NAMPT (0.49) | NAMPTHDAC1POLBSMN1; SMN2HTT | |
| SCHEMBL15673962 | 0.71 | HDAC1 (0.46) | NAMPTHDAC1MEN1KMT2AHDAC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009061448-A9 | METHODS AND COMPOSITIONS FOR THE TREATMENT OF PROTEINURIC DISEASES | THE GENERAL HOSPITAL CORPORATION (US) | 2009-08-13 | — | — | WO | disclosed |