Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKCQ | Q04759 | 15/20 | 0.65 |
| ▸ | SIRT5 | Q9NXA8 | 2/20 | 0.60 |
| ▸ | GSK3B | P49841 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | EGFR | P00533 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4387931 | 0.87 | PRKCQ (0.67) | PRKCQSIRT5GSK3BMAPT | |
| SCHEMBL4392873 | 0.87 | PRKCQ (0.67) | PRKCQSIRT5 | |
| SCHEMBL4387612 | 0.87 | PRKCQ (0.68) | PRKCQSIRT5GSK3B | |
| SCHEMBL4380044 | 0.86 | PRKCQ (0.69) | PRKCQSIRT5 | |
| SCHEMBL4384306 | 0.82 | PRKCQ (0.53) | PRKCQ | |
| SCHEMBL3183582 | 0.81 | SIRT5 (0.65) | PRKCQSIRT5GSK3BMAPT | |
| SCHEMBL3971786 | 0.80 | PIN1 (0.65) | PRKCQSIRT5MAPTEGFR | |
| SCHEMBL5416389 | 0.80 | STK17A (0.67) | PRKCQSIRT5GSK3BMAPT | |
| SCHEMBL3285968 | 0.80 | PRKCQ (1.00) | PRKCQGSK3B | |
| SCHEMBL13671799 | 0.80 | PRKCQ (0.85) | PRKCQGSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2131844-A1 | PTERIDINONE DERIVATIVES FOR USE AS STEAROYL CoA DESATURASE INHIBITORS | CV Therapeutics Inc. (US) | 2009-12-16 | — | — | EP | disclosed |
| WO-2008123891-A1 | PTERIDINONE DERIVATIVES FOR USE AS STEAROYL CoA DESATURASE INHIBITORS | CV THERAPEUTICS, INC. (US) | 2008-10-16 | — | — | WO | disclosed |