Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.35 |
| ▸ | IDO1 | P14902 | 4/20 | 0.34 |
| ▸ | CA12 | O43570 | 5/20 | 0.33 |
| ▸ | CA1 | P00915 | 5/20 | 0.33 |
| ▸ | CA2 | P00918 | 5/20 | 0.33 |
| ▸ | CA9 | Q16790 | 5/20 | 0.33 |
| ▸ | PTPRB | P23467 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 2/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.30 |
| ▸ | BCHE | P06276 | 1/20 | 0.30 |
| ▸ | CNR2 | P34972 | 1/20 | 0.30 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | HTT | P42858 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21528087 | 0.67 | IDO1 (0.43) | IDO1CA12CA1CA2CA9 | |
| SCHEMBL3816675 | 0.67 | LMNA (0.55) | MAPTKDM4ELMNAALDH1A1MAPK1 | |
| SCHEMBL4385104 | 0.67 | BRD4 (0.38) | MALT1IDO1ALDH1A1 | |
| SCHEMBL19487331 | 0.66 | HTT (0.54) | IDO1MAPTKDM4EGPBAR1LMNA | |
| SCHEMBL13306470 | 0.66 | IDO1 (0.46) | MALT1IDO1CA12CA1CA2 | |
| SCHEMBL13306468 | 0.66 | MAPT (0.48) | IDO1CA12CA1CA2CA9 | |
| SCHEMBL3289243 | 0.66 | LMNA (0.40) | MALT1IDO1MAPTNPSR1KDM4E | |
| SCHEMBL7894530 | 0.65 | MTNR1A (0.48) | MALT1IDO1CA12CA1CA2 | |
| SCHEMBL13306469 | 0.65 | PDPK1 (0.45) | MALT1IDO1CA12CA1CA2 | |
| SCHEMBL445683 | 0.65 | ALDH1A1 (0.48) | IDO1CA12CA1CA2CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1628990-B1 | NOVEL 14 AND 15 MEMBERED RING COMPOUNDS | GLAXO GROUP LTD (GB) | 2009-12-02 | — | — | EP | disclosed |
| US-20070141276-A1 | Novel 14 and 15 membered ring compounds | GLAXO GROUP LIMITED (GB) | 2007-06-21 | — | — | US | disclosed |