Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 2/20 | 0.38 |
| ▸ | IDO1 | P14902 | 4/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.34 |
| ▸ | DDB1 | Q16531 | 2/20 | 0.34 |
| ▸ | CRBN | Q96SW2 | 2/20 | 0.34 |
| ▸ | TPSAB1 | Q15661 | 1/20 | 0.33 |
| ▸ | TPSD1 | Q9BZJ3 | 1/20 | 0.33 |
| ▸ | TPSG1 | Q9NRR2 | 1/20 | 0.33 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.33 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.33 |
| ▸ | RORC | P51449 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.32 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.32 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.32 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6689539 | 0.76 | IDO1 (0.36) | BRD4IDO1ALDH1A1MEN1TSHR | |
| SCHEMBL3816675 | 0.70 | LMNA (0.55) | ALDH1A1MEN1TSHRKMT2AGAA | |
| SCHEMBL21528087 | 0.68 | IDO1 (0.43) | IDO1ALDH1A1MEN1KMT2AGAA | |
| SCHEMBL4399700 | 0.68 | ALDH1A1 (0.38) | IDO1ALDH1A1MEN1KMT2AGAA | |
| SCHEMBL19487331 | 0.67 | HTT (0.54) | IDO1ALDH1A1TSHRKMT2AGAA | |
| SCHEMBL13306470 | 0.67 | IDO1 (0.46) | IDO1ALDH1A1MALT1 | |
| SCHEMBL3289243 | 0.67 | LMNA (0.40) | BRD4IDO1ALDH1A1MEN1KMT2A | |
| SCHEMBL4385107 | 0.67 | MALT1 (0.35) | IDO1ALDH1A1MALT1 | |
| SCHEMBL7894530 | 0.67 | MTNR1A (0.48) | IDO1ALDH1A1MALT1 | |
| SCHEMBL13306469 | 0.66 | PDPK1 (0.45) | IDO1ALDH1A1MEN1KMT2AMALT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1628990-B1 | NOVEL 14 AND 15 MEMBERED RING COMPOUNDS | GLAXO GROUP LTD (GB) | 2009-12-02 | — | — | EP | disclosed |
| US-20070141276-A1 | Novel 14 and 15 membered ring compounds | GLAXO GROUP LIMITED (GB) | 2007-06-21 | — | — | US | disclosed |