SCHEMBL4385356

SCHEMBL4385356

COC(=O)Oc1ccccc1C(=O)Oc1ccc(C)cc1

nearest known ligand 0.61

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HPGD P15428 3/20 0.61
XBP1 P17861 1/20 0.61
HSD17B10 Q99714 3/20 0.59
KDM4E B2RXH2 1/20 0.59
CYP1A2 P05177 1/20 0.57
CYP3A4 P08684 1/20 0.57
CYP2C9 P11712 1/20 0.57
CYP2C19 P33261 1/20 0.57
MAPT P10636 2/20 0.57
NPSR1 Q6W5P4 2/20 0.57
PTK2B Q14289 1/20 0.55
RXFP1 Q9HBX9 1/20 0.55
TP53 P04637 1/20 0.51
GAA P10253 1/20 0.51
KMT2A Q03164 5/20 0.50
MEN1 O00255 2/20 0.50
PTGS2 P35354 1/20 0.50
ESR1 P03372 1/20 0.49
SLC6A3 Q01959 1/20 0.49
ALDH1A1 P00352 3/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4394452 0.91 PTK2B (0.57) HPGDXBP1HSD17B10KDM4ECYP1A2
SCHEMBL4384041 0.89 HSD17B10 (0.70) HPGDXBP1HSD17B10KDM4ECYP1A2
SCHEMBL13971012 0.88 PTK2B (0.55) HPGDXBP1HSD17B10KDM4ECYP1A2
SCHEMBL4390471 0.88 PTK2B (0.55) HPGDXBP1HSD17B10KDM4ECYP1A2
SCHEMBL4384563 0.88 SLC6A3 (0.56) HPGDXBP1HSD17B10KDM4ECYP1A2
SCHEMBL5694595 0.88 SLC6A3 (0.56) HPGDXBP1HSD17B10KDM4ECYP1A2
SCHEMBL4389475 0.87 NPSR1 (0.72) HPGDXBP1CYP1A2CYP3A4CYP2C9
SCHEMBL4393205 0.85 PTK2B (0.52) HPGDXBP1HSD17B10CYP1A2CYP3A4
SCHEMBL21449134 0.84 PTGS2 (0.68) HPGDXBP1HSD17B10KDM4ECYP1A2
SCHEMBL4382990 0.83 CYP1A2 (0.65) HPGDXBP1CYP1A2CYP3A4CYP2C9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1829854-B1 PROCESS FOR PRODUCING AROMATIC CARBONATE ASAHI KASEI CHEMICALS CORP (JP) 2013-09-04 EP disclosed
US-7629485-B2 Process for producing aromatic carbonate ASAHI KASEI CHEMICALS CORPORATION (JP) 2009-12-08 US disclosed
US-20080177099-A1 Process for Producing Aromatic Carbonate ASAHI KASEI KABUSHIKI KAISHA (JP) 2008-07-24 US disclosed
EP-1829854-A1 PROCESS FOR PRODUCING AROMATIC CARBONATE Asahi Kasei Chemicals Corporation (JP) 2007-09-05 EP disclosed
EP-1016648-B1 PROCESS FOR THE PREPARATION OF AROMATIC CARBONATES ASAHI CHEMICAL IND (JP) 2003-05-14 EP disclosed
US-6262210-B1 TRANSESTERIFYING DIALKYL CARBONATE, ALKYL ARYL CARBONATE OR MIXTURE WITH AROMATIC MONOHYDROXY COMPOUND IN PRESENCE OF METAL CONTAINING CATALYST TO OBTAIN HIGH BOILING POINT REACTION MIXTURE CONTAINING AROMATIC CARBONATE ASAHI KASEI KOGYO KABUSHIKI KAISHA (JP) 2001-07-17 US disclosed
EP-1016648-A1 PROCESS FOR THE PREPARATION OF AROMATIC CARBONATES Asahi Kasei Kogyo Kabushiki Kaisha (JP) 2000-07-05 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20080177099-A1 Process for Producing Aromatic Carbonate DCLK1, ALK, DCLK3 HPGD 3545/4885XBP1 2580/4885HSD17B10 963/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.