Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 1/20 | 0.46 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.46 |
| ▸ | DRD2 | P14416 | 5/20 | 0.44 |
| ▸ | IDO1 | P14902 | 1/20 | 0.42 |
| ▸ | TACR1 | P25103 | 1/20 | 0.42 |
| ▸ | PTGER3 | P43115 | 2/20 | 0.41 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.41 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.39 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.39 |
| ▸ | PRKCB | P05771 | 1/20 | 0.39 |
| ▸ | CDK1 | P06493 | 1/20 | 0.39 |
| ▸ | LYN | P07948 | 1/20 | 0.39 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.39 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.39 |
| ▸ | CDK2 | P24941 | 1/20 | 0.39 |
| ▸ | GSK3B | P49841 | 1/20 | 0.39 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.39 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.39 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4963737 | 0.89 | TACR1 (0.40) | MTNR1AMTNR1BDRD2IDO1TACR1 | |
| SCHEMBL4387028 | 0.84 | HTR2A (0.45) | MTNR1AMTNR1BDRD2IDO1PTGER3 | |
| SCHEMBL4388802 | 0.83 | HTR6 (0.43) | MTNR1AMTNR1BIDO1TACR1PTGER3 | |
| SCHEMBL4389932 | 0.81 | HTR2A (0.46) | MTNR1AMTNR1BIDO1PTGER3 | |
| SCHEMBL25734922 | 0.79 | MTNR1A (0.73) | MTNR1AMTNR1BDRD2IDO1TACR1 | |
| SCHEMBL4974032 | 0.76 | HTR2A (0.45) | MTNR1AMTNR1BIDO1PTGER3 | |
| SCHEMBL1399346 | 0.75 | HTR2A (0.66) | MTNR1AMTNR1BIDO1PTGER3 | |
| SCHEMBL1399273 | 0.74 | KMT2A (0.49) | MTNR1AMTNR1BIDO1PTGER3 | |
| SCHEMBL4396116 | 0.72 | SLC6A4 (0.43) | IDO1PTGER3 | |
| SCHEMBL7846607 | 0.71 | FAAH (0.58) | MTNR1AIDO1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1893575-B1 | 2-(1H-INDOLYLSULFANYL)-ARYL AMINE DERIVATIVES | H LUNDBECK AS (DK) | 2017-01-11 | — | — | EP | disclosed |
| US-7629473-B2 | 2-(1H-indolylsulfanyl)-aryl amine derivatives | H. LUNDBECK A/S (DK) | 2009-12-08 | — | — | US | disclosed |
| US-20060287382-A1 | 2-(1H-indolylsulfanyl)-aryl amine derivatives | H. LUNDBECK A/S (DK) | 2006-12-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060287382-A1 | 2-(1H-indolylsulfanyl)-aryl amine derivatives | CYP11B2, CYP1A2, CYP4B1 | MTNR1A 193/4885MTNR1B 89/4885DRD2 1133/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.