Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FAAH | O00519 | 1/20 | 0.47 |
| ▸ | PLA2G2A | P14555 | 5/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.40 |
| ▸ | LMNA | P02545 | 4/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | RGS12 | O14924 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | GNAI1 | P63096 | 1/20 | 0.40 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.40 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4089413 | 0.90 | FAAH (0.56) | FAAHPLA2G2AALDH1A1LMNATSHR | |
| SCHEMBL4097799 | 0.90 | TUBB4A (0.47) | PLA2G2AALDH1A1LMNAMAPTTUBB4A | |
| SCHEMBL2993468 | 0.88 | PLA2G2A (0.56) | FAAHPLA2G2AALDH1A1LMNATSHR | |
| SCHEMBL3010224 | 0.88 | LMNA (0.48) | PLA2G2AALDH1A1LMNAMAPTTUBB4A | |
| SCHEMBL4099756 | 0.84 | FAAH (0.53) | FAAHPLA2G2AALDH1A1LMNATSHR | |
| SCHEMBL4083902 | 0.83 | FAAH (0.51) | FAAHPLA2G2AALDH1A1LMNATSHR | |
| SCHEMBL4098078 | 0.83 | TUBB4A (0.51) | PLA2G2AALDH1A1LMNAMAPTKMT2A | |
| SCHEMBL4083410 | 0.82 | PDE4A (0.47) | PLA2G2AALDH1A1LMNAMAPTCYP1A2 | |
| SCHEMBL3007999 | 0.78 | FAAH (0.54) | FAAHPLA2G2AALDH1A1LMNATSHR | |
| SCHEMBL4378501 | 0.78 | FAAH (0.47) | FAAHPLA2G2AALDH1A1LMNATSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2049520-A2 | INDOLE COMPOUNDS | Ironwood Pharmaceuticals, Inc. (US) | 2009-04-22 | — | — | EP | disclosed |
| WO-2008019357-A2 | INDOLE COMPOUNDS | IRONWOOD PHARMACEUTICALS, INC. (US) | 2008-02-14 | — | — | WO | disclosed |