Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | TDP2 | O95551 | 1/20 | 0.38 |
| ▸ | CASP3 | P42574 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | UCHL1 | P09936 | 1/20 | 0.36 |
| ▸ | UCHL3 | P15374 | 1/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.36 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.36 |
| ▸ | MDM2 | Q00987 | 2/20 | 0.35 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.35 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.35 |
| ▸ | EIF4H | Q15056 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4399700 | 0.79 | ALDH1A1 (0.38) | ALDH1A1MEN1KMT2AKDM4EGAA | |
| SCHEMBL4399697 | 0.79 | ALDH1A1 (0.38) | ALDH1A1MEN1KMT2AKDM4EGAA | |
| SCHEMBL4385104 | 0.73 | BRD4 (0.38) | ALDH1A1MEN1KMT2AGAAATM | |
| SCHEMBL18955128 | 0.72 | ALDH1A1 (0.58) | ALDH1A1CASP3MEN1KMT2AMAPT | |
| SCHEMBL30099632 | 0.72 | GABRG2 (0.41) | ALDH1A1TDP2MEN1KMT2AKDM4E | |
| SCHEMBL23609872 | 0.72 | GABRG2 (0.41) | ALDH1A1TDP2MEN1KMT2AKDM4E | |
| SCHEMBL2743830 | 0.71 | ALDH1A1 (0.47) | ALDH1A1MEN1KMT2AKDM4EGAA | |
| SCHEMBL18955409 | 0.71 | ALDH1A1 (0.76) | ALDH1A1CASP3KMT2AMAPTHSD17B10 | |
| SCHEMBL5059322 | 0.71 | TDP2 (0.40) | ALDH1A1TDP2MEN1KMT2AKDM4E | |
| SCHEMBL10746773 | 0.70 | ALDH1A1 (0.40) | ALDH1A1TDP2MEN1KMT2AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1628990-B1 | NOVEL 14 AND 15 MEMBERED RING COMPOUNDS | GLAXO GROUP LTD (GB) | 2009-12-02 | — | — | EP | disclosed |
| US-20070141276-A1 | Novel 14 and 15 membered ring compounds | GLAXO GROUP LIMITED (GB) | 2007-06-21 | — | — | US | disclosed |
| EP-1628990-A1 | NOVEL 14 AND 15 MEMBERED RING COMPOUNDS | GLAXO GROUP LIMITED (GB) | 2006-03-01 | — | — | EP | disclosed |
| WO-2004101588-A1 | NOVEL 14 AND 15 MEMBERED RING COMPOUNDS | GLAXO GROUP LIMITED (GB) | 2004-11-25 | — | — | WO | disclosed |