Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | TTR | P02766 | 1/20 | 0.36 |
| ▸ | DPP4 | P27487 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 5/20 | 0.35 |
| ▸ | RAB9A | P51151 | 5/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | IDO1 | P14902 | 1/20 | 0.34 |
| ▸ | TDO2 | P48775 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | MAOB | P27338 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | RXRA | P19793 | 3/20 | 0.33 |
| ▸ | CA12 | O43570 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4399697 | 1.00 | ALDH1A1 (0.38) | ALDH1A1TTRDPP4NPC1RAB9A | |
| SCHEMBL4386782 | 0.79 | ALDH1A1 (0.40) | ALDH1A1MAPTKDM4EMEN1KMT2A | |
| SCHEMBL4385104 | 0.68 | BRD4 (0.38) | ALDH1A1IDO1MEN1KMT2AGAA | |
| SCHEMBL30099632 | 0.66 | GABRG2 (0.41) | ALDH1A1IDO1TDO2SMN1; SMN2MAPT | |
| SCHEMBL23609872 | 0.66 | GABRG2 (0.41) | ALDH1A1IDO1TDO2SMN1; SMN2MAPT | |
| SCHEMBL2743830 | 0.66 | ALDH1A1 (0.47) | ALDH1A1SMN1; SMN2MAPTKDM4EMEN1 | |
| SCHEMBL5059322 | 0.65 | TDP2 (0.40) | ALDH1A1SMN1; SMN2MAPTKDM4EMEN1 | |
| SCHEMBL10746773 | 0.65 | ALDH1A1 (0.40) | ALDH1A1NPC1RAB9ASMN1; SMN2LMNA | |
| SCHEMBL6938561 | 0.64 | ALDH1A1 (0.44) | ALDH1A1POLBLMNAMAPTHTT | |
| SCHEMBL9665346 | 0.63 | USP2 (0.40) | ALDH1A1MAPTKDM4EHTTGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1628990-B1 | NOVEL 14 AND 15 MEMBERED RING COMPOUNDS | GLAXO GROUP LTD (GB) | 2009-12-02 | — | — | EP | disclosed |
| US-20070141276-A1 | Novel 14 and 15 membered ring compounds | GLAXO GROUP LIMITED (GB) | 2007-06-21 | — | — | US | disclosed |
| EP-1628990-A1 | NOVEL 14 AND 15 MEMBERED RING COMPOUNDS | GLAXO GROUP LIMITED (GB) | 2006-03-01 | — | — | EP | disclosed |
| WO-2004101588-A1 | NOVEL 14 AND 15 MEMBERED RING COMPOUNDS | GLAXO GROUP LIMITED (GB) | 2004-11-25 | — | — | WO | disclosed |