Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 4/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | PLA2G2A | P14555 | 2/20 | 0.38 |
| ▸ | FAAH | O00519 | 1/20 | 0.38 |
| ▸ | EDNRB | P24530 | 2/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.36 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3008455 | 0.96 | MEN1 (0.42) | MEN1KMT2APOLBKCNH2NPC1 | |
| SCHEMBL2997974 | 0.95 | KCNH2 (0.44) | MEN1KMT2AKCNH2NPC1RAB9A | |
| SCHEMBL3010861 | 0.92 | MEN1 (0.44) | MEN1KMT2APOLBPLA2G2AFAAH | |
| SCHEMBL2995848 | 0.91 | KMT2A (0.45) | MEN1KMT2AKCNH2NPC1RAB9A | |
| SCHEMBL2996462 | 0.90 | KCNH2 (0.45) | MEN1KMT2AKCNH2NPC1RAB9A | |
| SCHEMBL3008903 | 0.89 | MEN1 (0.41) | MEN1KMT2APOLBEDNRBMAPT | |
| SCHEMBL3008225 | 0.89 | PLA2G2A (0.45) | MEN1KMT2AKCNH2NPC1RAB9A | |
| SCHEMBL3002874 | 0.89 | PTGS2 (0.46) | PLA2G2AFAAHEDNRBMAPTHTT | |
| SCHEMBL3005046 | 0.88 | FAAH (0.41) | MEN1KMT2APOLBFAAHHTT | |
| SCHEMBL3001593 | 0.88 | L3MBTL1 (0.41) | MEN1KMT2AFAAHMAPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2049520-A2 | INDOLE COMPOUNDS | Ironwood Pharmaceuticals, Inc. (US) | 2009-04-22 | — | — | EP | disclosed |
| WO-2008019357-A2 | INDOLE COMPOUNDS | IRONWOOD PHARMACEUTICALS, INC. (US) | 2008-02-14 | — | — | WO | disclosed |