Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RORC | P51449 | 1/20 | 0.47 |
| ▸ | ATR | Q13535 | 4/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | GPR119 | Q8TDV5 | 3/20 | 0.43 |
| ▸ | ADAMTS7 | Q9UKP4 | 2/20 | 0.40 |
| ▸ | ADAMTS5 | Q9UNA0 | 2/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | ACHE | P22303 | 1/20 | 0.39 |
| ▸ | L3MBTL3 | Q96JM7 | 1/20 | 0.39 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.39 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.39 |
| ▸ | BRAF | P15056 | 1/20 | 0.39 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4060086 | 0.90 | RORC (0.46) | RORCATRGPR119 | |
| SCHEMBL5079950 | 0.87 | GPR119 (0.47) | RORCATRLMNAGPR119ADAMTS7 | |
| SCHEMBL13690530 | 0.87 | ATR (0.47) | ATRTSHRACHEL3MBTL3MKNK1 | |
| SCHEMBL4056917 | 0.87 | NPY2R (0.48) | RORCGPR119 | |
| SCHEMBL4370431 | 0.85 | ATR (0.50) | ATRGPR119L3MBTL3MKNK1MKNK2 | |
| SCHEMBL4058099 | 0.85 | RORC (0.47) | RORCGPR119SMN1; SMN2 | |
| SCHEMBL4053567 | 0.84 | GPR119 (0.47) | RORCLMNAGPR119TSHRSMN1; SMN2 | |
| SCHEMBL4048482 | 0.83 | GPR119 (0.56) | RORCGPR119 | |
| SCHEMBL4376368 | 0.81 | MKNK1 (0.46) | ATRL3MBTL3MKNK1MKNK2 | |
| SCHEMBL4049314 | 0.81 | GPR119 (0.49) | RORCGPR119 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009106561-A1 | PYRAZINE COMPOUNDS FOR TREATING GPR119 RELATED DISORDERS | BIOVITRUM AB (PUBL) (SE) | 2009-09-03 | — | — | WO | disclosed |
| WO-2009106561-A1 | PYRAZINE COMPOUNDS FOR TREATING GPR119 RELATED DISORDERS | BIOVITRUM AB (PUBL) (SE) | 2009-09-03 | — | — | WO | disclosed |