Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MKNK1 | Q9BUB5 | 14/20 | 0.46 |
| ▸ | MKNK2 | Q9HBH9 | 14/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | ATR | Q13535 | 3/20 | 0.43 |
| ▸ | L3MBTL3 | Q96JM7 | 1/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13690552 | 0.88 | GPR119 (0.49) | — | |
| SCHEMBL4056589 | 0.86 | ATR (0.40) | MKNK1MKNK2ATRL3MBTL3 | |
| SCHEMBL4050800 | 0.86 | ALDH1A1 (0.41) | ATR | |
| SCHEMBL13690530 | 0.85 | ATR (0.47) | MKNK1MKNK2ATRL3MBTL3KCNH2 | |
| SCHEMBL4050702 | 0.85 | GPR119 (0.46) | MKNK1MKNK2ATRKCNH2 | |
| SCHEMBL4370431 | 0.83 | ATR (0.50) | MKNK1MKNK2ATRL3MBTL3 | |
| SCHEMBL4053316 | 0.83 | ATR (0.41) | MKNK1MKNK2ATRL3MBTL3 | |
| SCHEMBL4374631 | 0.83 | ITGB3 (0.40) | ATR | |
| SCHEMBL4060086 | 0.82 | RORC (0.46) | ATR | |
| SCHEMBL4370580 | 0.82 | ATR (0.34) | MKNK1MKNK2ATR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009106561-A1 | PYRAZINE COMPOUNDS FOR TREATING GPR119 RELATED DISORDERS | BIOVITRUM AB (PUBL) (SE) | 2009-09-03 | — | — | WO | disclosed |