Known targets — ChEMBL curated mechanism
AGTR1DHFRGABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTNR3C2PBP2XPTGS1PTGS2VKORC1blablaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAftsImrcAmrcBmrdApbp1apbp1bpbp2apbp2bpbp3polthyA
The experimentally established mechanism targets of Potassium Ion. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 8/20 | 0.84 |
| ▸ | MEN1 | O00255 | 7/20 | 0.84 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.84 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.84 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.84 |
| ▸ | POLB | P06746 | 3/20 | 0.84 |
| ▸ | HTT | P42858 | 2/20 | 0.84 |
| ▸ | LMNA | P02545 | 1/20 | 0.84 |
| ▸ | EGFR | P00533 | 1/20 | 0.56 |
| ▸ | NPC1 | O15118 | 4/20 | 0.51 |
| ▸ | RAB9A | P51151 | 4/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.49 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.49 |
| ▸ | RECQL | P46063 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | GLA | P06280 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.43 |
| ▸ | NOS1 | P29475 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29366468 | 0.92 | MAPT (1.00) | MAPTMEN1KMT2AALDH1A1NPSR1 | |
| SCHEMBL1289510 | 0.92 | MAPT (1.00) | MAPTMEN1KMT2AALDH1A1NPSR1 | |
| SCHEMBL1289511 | 0.92 | MAPT (1.00) | MAPTMEN1KMT2AALDH1A1NPSR1 | |
| SCHEMBL8827154 | 0.86 | MAPT (0.89) | MAPTMEN1KMT2AALDH1A1NPSR1 | |
| SCHEMBL8827131 | 0.86 | MAPT (0.89) | MAPTMEN1KMT2AALDH1A1NPSR1 | |
| SCHEMBL13758730 | 0.85 | MAPT (0.86) | MAPTMEN1KMT2AALDH1A1NPSR1 | |
| SCHEMBL11694225 | 0.81 | ALDH1A1 (0.79) | MAPTMEN1KMT2AALDH1A1NPSR1 | |
| SCHEMBL11694220 | 0.81 | ALDH1A1 (0.79) | MAPTMEN1KMT2AALDH1A1NPSR1 | |
| Potassium Ion SCHEMBL4388158 | 0.81 | MEN1 (0.54) | MAPTMEN1KMT2AALDH1A1NPSR1 | |
| SCHEMBL4846701 | 0.78 | MEN1 (0.74) | MAPTMEN1KMT2AALDH1A1NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7629400-B2 | Image making medium | HYMAN SYDNEY | 2009-12-08 | — | — | US | disclosed |
| US-20030035917-A1 | Image making medium | HYMAN SYDNEY (US) | 2003-02-20 | — | — | US | disclosed |