Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAAR1 | Q96RJ0 | 7/20 | 0.50 |
| ▸ | HTR2A | P28223 | 3/20 | 0.49 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.49 |
| ▸ | HTR2C | P28335 | 1/20 | 0.42 |
| ▸ | HTR2B | P41595 | 1/20 | 0.42 |
| ▸ | CXCR3 | P49682 | 1/20 | 0.42 |
| ▸ | MAOB | P27338 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | HTR1A | P08908 | 1/20 | 0.41 |
| ▸ | HTR7 | P34969 | 1/20 | 0.41 |
| ▸ | HTR6 | P50406 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | GAPDH | P04406 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | APEX1 | P27695 | 1/20 | 0.40 |
| ▸ | RAD52 | P43351 | 1/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.40 |
| ▸ | BLM | P54132 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL16401793 | 0.98 | TAAR1 (0.48) | TAAR1HTR2ATRPM8HTR2CHTR2B | |
| SCHEMBL6194409 | 0.88 | CHEK1 (0.41) | TAAR1HTR2ATRPM8HTR2CHTR2B | |
| Hydrochloric Acid SCHEMBL4933843 | 0.86 | HTR2A (0.42) | TAAR1HTR2ATRPM8HTR2CHTR2B | |
| SCHEMBL1570195 | 0.84 | TAAR1 (0.52) | TAAR1HTR2ATRPM8HTR2CHTR2B | |
| SCHEMBL30474185 | 0.84 | CYP2A6 (0.44) | TAAR1HTR2ATRPM8HTR2CHTR2B | |
| SCHEMBL992833 | 0.84 | CYP2A6 (0.44) | TAAR1HTR2ATRPM8HTR2CHTR2B | |
| Hydrochloric Acid SCHEMBL5957928 | 0.83 | HTR2A (0.46) | TAAR1HTR2ATRPM8HTR2CHTR2B | |
| SCHEMBL18482277 | 0.83 | HTR2A (0.41) | HTR2AHTR2CHTR2BCXCR3TP53 | |
| SCHEMBL25322706 | 0.81 | HTR2A (0.43) | HTR2AHTR2CCXCR3TP53HTR1A | |
| SCHEMBL3126933 | 0.81 | HTR2A (0.40) | HTR2AHTR2CHTR2BCXCR3TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10952435-B2 | Pyridine-2-carboxamides as nematocides | SYNGENTA PARTICIPATIONS AG (CH) | 2021-03-23 | — | — | US | disclosed |
| US-10952435-B2 | Pyridine-2-carboxamides as nematocides | SYNGENTA PARTICIPATIONS AG (CH) | 2021-03-23 | — | — | US | disclosed |
| EP-3022181-B1 | PYRIDINE-2-CARBOXAMIDES AS NEMATOCIDES | SYNGENTA PARTICIPATIONS AG (CH) | 2018-03-07 | — | — | EP | disclosed |
| EP-3022181-B1 | PYRIDINE-2-CARBOXAMIDES AS NEMATOCIDES | SYNGENTA PARTICIPATIONS AG (CH) | 2018-03-07 | — | — | EP | disclosed |
| US-20160165887-A1 | PYRIDINE-2-CARBOXAMIDES AS NEMATOCIDES | SYNGENTA PARTICIPATIONS AG (CH) | 2016-06-16 | — | — | US | disclosed |
| US-20160165887-A1 | PYRIDINE-2-CARBOXAMIDES AS NEMATOCIDES | SYNGENTA PARTICIPATIONS AG (CH) | 2016-06-16 | — | — | US | disclosed |
| US-20160165887-A1 | PYRIDINE-2-CARBOXAMIDES AS NEMATOCIDES | SYNGENTA PARTICIPATIONS AG (CH) | 2016-06-16 | — | — | US | disclosed |
| EP-3022181-A1 | PYRIDINE-2-CARBOXAMIDES AS NEMATOCIDES | Syngenta Participations AG (CH) | 2016-05-25 | — | — | EP | disclosed |
| WO-2015007626-A1 | PYRIDINE-2-CARBOXAMIDES AS NEMATOCIDES | SYNGENTA PARTICIPATIONS AG (CH) | 2015-01-22 | — | — | WO | disclosed |
| WO-2015007626-A1 | PYRIDINE-2-CARBOXAMIDES AS NEMATOCIDES | SYNGENTA PARTICIPATIONS AG (CH) | 2015-01-22 | — | — | WO | disclosed |
| WO-2015004091-A1 | NICOTINAMIDE DERIVATIVES AND THEIR USE AGAINST NEMATODES | SYNGENTA PARTICIPATIONS AG (CH) | 2015-01-15 | — | — | WO | disclosed |
| US-7629358-B2 | Compounds useful for the treatment of diseases | PFIZER INC (US) | 2009-12-08 | — | — | US | disclosed |
| US-7629358-B2 | Compounds useful for the treatment of diseases | PFIZER INC (US) | 2009-12-08 | — | — | US | disclosed |
| US-7629358-B2 | Compounds useful for the treatment of diseases | PFIZER INC (US) | 2009-12-08 | — | — | US | disclosed |
| CN-1942432-A | Phenylethanolamine derivatives as beta-2 agonists | PFIZER LTD (US) | 2007-04-04 | — | — | CN | disclosed |
| EP-1727789-A2 | PHENYLETHANOLAMINE DERIVATIVES AS BETA-2 AGONISTS | Pfizer Limited (GB) | 2006-12-06 | — | — | EP | disclosed |
| US-20050234097-A1 | Compounds useful for the treatment of diseases | PFIZER INC | 2005-10-20 | — | — | US | disclosed |
| WO-2005090287-A2 | PHENYLETHANOLAMINE DERIVATIVES AS BETA-2 AGONISTS | PFIZER LIMITED (GB) | 2005-09-29 | — | — | WO | disclosed |
| WO-2001009127-A1 | BENZOXAZINE DERIVATIVES AND THEIR THERAPEUTIC USE | AVENTIS PHARMA S.A. (FR) | 2001-02-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050234097-A1 | Compounds useful for the treatment of diseases | LTC4S, CYP11B2, CYP11B1 | TAAR1 1799/4885HTR2A 3843/4885TRPM8 2269/4885 |
| US-20160165887-A1 | PYRIDINE-2-CARBOXAMIDES AS NEMATOCIDES | TUBA3C, CYCS, ACHE | TAAR1 1176/4885HTR2A 2046/4885TRPM8 1518/4885 |
| US-10952435-B2 | Pyridine-2-carboxamides as nematocides | TUBA3C, CYCS, ACHE | TAAR1 1176/4885HTR2A 2046/4885TRPM8 1518/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.