Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 2/20 | 0.65 |
| ▸ | RXFP1 | Q9HBX9 | 3/20 | 0.62 |
| ▸ | GAA | P10253 | 3/20 | 0.62 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.58 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.57 |
| ▸ | AURKA | O14965 | 1/20 | 0.55 |
| ▸ | TSHR | P16473 | 1/20 | 0.52 |
| ▸ | HTT | P42858 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.52 |
| ▸ | NPC1 | O15118 | 2/20 | 0.52 |
| ▸ | RAB9A | P51151 | 2/20 | 0.52 |
| ▸ | MAPT | P10636 | 4/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | ATM | Q13315 | 2/20 | 0.48 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.48 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.48 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.48 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL438198 | 0.87 | MAPK1 (0.63) | MAPK1GAANPSR1ALDH1A1SMN1; SMN2 | |
| SCHEMBL529424 | 0.86 | MAPK1 (0.66) | MAPK1RXFP1GAANPSR1ALDH1A1 | |
| SCHEMBL437947 | 0.86 | KMT2A (0.53) | MAPK1GAANPSR1ALDH1A1SMN1; SMN2 | |
| SCHEMBL439008 | 0.85 | NMT2 (0.60) | MAPK1GAANPSR1ALDH1A1SMN1; SMN2 | |
| SCHEMBL401916 | 0.85 | MAPK1 (0.65) | MAPK1RXFP1GAANPSR1ALDH1A1 | |
| SCHEMBL437781 | 0.85 | MAPT (0.61) | GAANPSR1ALDH1A1SMN1; SMN2KMT2A | |
| SCHEMBL441687 | 0.85 | KMT2A (0.62) | MAPK1GAANPSR1ALDH1A1SMN1; SMN2 | |
| SCHEMBL438203 | 0.84 | MAPT (0.62) | GAANPSR1ALDH1A1SMN1; SMN2HTT | |
| SCHEMBL10281891 | 0.83 | HTT (0.49) | MAPK1RXFP1GAANPSR1ALDH1A1 | |
| SCHEMBL23234973 | 0.82 | MAPK1 (0.76) | MAPK1RXFP1GAANPSR1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3140303-B1 | IMIDAZO[4,5-C]QUINOLIN-2-ONE COMPOUNDS AND THEIR USE IN TREATING CANCER | ASTRAZENECA AB (SE) | 2018-03-28 | — | — | EP | disclosed |
| US-20120065166-A1 | Bone Modulators And Methods Therewith | ESPINA VIRGINIA (US) | 2012-03-15 | — | — | US | disclosed |