Sugi Predict

Sugi Predict / Compounds / SCHEMBL438203

SCHEMBL438203

SCHEMBL438203

CCOC(=O)c1cnc2ccc(OC)cc2c1N

nearest known ligand 0.62

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ MAPT P10636 9/20 0.62
▸ ALDH1A1 P00352 6/20 0.62
▸ HPGD P15428 4/20 0.62
▸ SMN1; SMN2 Q16637 3/20 0.62
▸ LMNA P02545 3/20 0.62
▸ KDM4E B2RXH2 2/20 0.62
▸ TDP1 Q9NUW8 1/20 0.62
▸ NMT1 P30419 2/20 0.61
▸ TP53 P04637 3/20 0.60
▸ KMT2A Q03164 4/20 0.57
▸ NPSR1 Q6W5P4 2/20 0.56
▸ HTT P42858 1/20 0.56
▸ CLK1 P49759 1/20 0.56
▸ GAA P10253 2/20 0.54
▸ MEN1 O00255 2/20 0.54
▸ THRB P10828 1/20 0.54
▸ SLC2A1 P11166 1/20 0.54
▸ NMT2 O60551 1/20 0.53
▸ RAB9A P51151 2/20 0.53
▸ L3MBTL1 Q9Y468 1/20 0.52

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL437781 0.91 MAPT (0.61) MAPTALDH1A1HPGDSMN1; SMN2LMNA
SCHEMBL620981 0.88 NMT1 (0.53) MAPTALDH1A1HPGDSMN1; SMN2LMNA
SCHEMBL621322 0.88 NMT1 (0.54) MAPTALDH1A1HPGDSMN1; SMN2LMNA
SCHEMBL31603107 0.86 MAPT (0.63) MAPTALDH1A1HPGDSMN1; SMN2LMNA
SCHEMBL620359 0.86 MAPT (0.63) MAPTALDH1A1HPGDSMN1; SMN2LMNA
SCHEMBL619241 0.86 NMT1 (0.58) MAPTALDH1A1HPGDSMN1; SMN2LMNA
SCHEMBL438198 0.86 MAPK1 (0.63) MAPTALDH1A1SMN1; SMN2LMNAKDM4E
SCHEMBL2947439 0.85 MAPT (0.62) MAPTALDH1A1HPGDSMN1; SMN2LMNA
SCHEMBL544894 0.85 MAPT (0.62) MAPTALDH1A1HPGDSMN1; SMN2LMNA
SCHEMBL437947 0.85 KMT2A (0.53) MAPTALDH1A1HPGDSMN1; SMN2LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 29 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2603098-B1 METHOD OF IMPROVING STABILITY OF SWEET ENHANCER AND COMPOSITION CONTAINING STABILIZED SWEET ENHANCER FIRMENICH INCORPORATED (US) 2025-08-06 — — EP disclosed
US-11129397-B2 Method of improving stability of sweet enhancer and composition containing stabilized sweet enhancer FIREMENICH INCORPORATED (US) 2021-09-28 — — US disclosed
CN-106107406-B Methods of improving the stability of sweetness enhancers and compositions comprising stable sweetness enhancers 弗门尼舍公司 2020-06-09 — — CN disclosed
EP-2552207-B1 SWEET FLAVOR MODIFIER FIRMENICH INCORPORATED (US) 2019-08-21 — — EP disclosed
US-20190208802-A1 METHOD OF IMPROVING STABILITY OF SWEET ENHANCER AND COMPOSITION CONTAINING STABILIZED SWEET ENHANCER FIRMENICH INCORPORATED 2019-07-11 — — US disclosed
US-10244779-B2 Method of improving stability of sweet enhancer and composition containing stabilized sweet enhancer SENOMYX, INC. (US) 2019-04-02 — — US disclosed
US-9902737-B2 Sweet flavor modifier SENOMYX, INC. (US) 2018-02-27 — — US disclosed
US-9834544-B2 Sweet flavor modifier SENOMYX, INC. (US) 2017-12-05 — — US disclosed
EP-2742026-B1 SWEET FLAVOR MODIFIER SENOMYX INC (US) 2016-10-05 — — EP disclosed
US-20160251372-A1 SWEET FLAVOR MODIFIER FIRMENICH INCORPORATED 2016-09-01 — — US disclosed
EP-2603098-A2 METHOD OF IMPROVING STABILITY OF SWEET ENHANCER AND COMPOSITION CONTAINING STABILIZED SWEET ENHANCER Senomyx, Inc. (US) 2013-06-19 — — EP disclosed
WO-2013025560-A1 SWEET FLAVOR MODIFIER SENOMYX, INC. (US) 2013-02-21 — — WO disclosed
US-20130041046-A1 SWEET FLAVOR MODIFIER SENOMYX, INC. (US) 2013-02-14 — — US disclosed
CN-102933081-A Sweet flavor modifier SENOMYX INC 2013-02-13 — — CN disclosed
EP-2552207-A1 SWEET FLAVOR MODIFIER Senomyx, Inc. (US) 2013-02-06 — — EP disclosed
US-20120065166-A1 Bone Modulators And Methods Therewith ESPINA VIRGINIA (US) 2012-03-15 — — US disclosed
US-20120041078-A1 METHOD OF IMPROVING STABILITY OF SWEET ENHANCER AND COMPOSITION CONTAINING STABILIZED SWEET ENHANCER SENOMYX, INC. (US) 2012-02-16 — — US disclosed
WO-2012021837-A2 METHOD OF IMPROVING STABILITY OF SWEET ENHANCER AND COMPOSITION CONTAINING STABILIZED SWEET ENHANCER SENOMYX, INC. (US) 2012-02-16 — — WO disclosed
WO-2011123693-A1 SWEET FLAVOR MODIFIER SENOMYX, INC. (US) 2011-10-06 — — WO disclosed
US-20110245353-A1 SWEET FLAVOR MODIFIER SENOMYS, INC. (US) 2011-10-06 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10244779-B2 Method of improving stability of sweet enhancer and composition containing stabilized sweet enhancer TFEB, TREH, SLC2A8 MAPT 1864/4885ALDH1A1 3324/4885HPGD 3816/4885
US-20120041078-A1 METHOD OF IMPROVING STABILITY OF SWEET ENHANCER AND COMPOSITION CONTAINING STABILIZED SWEET ENHANCER TFEB, TREH, SLC2A8 MAPT 1864/4885ALDH1A1 3324/4885HPGD 3816/4885
US-20110245353-A1 SWEET FLAVOR MODIFIER TAS2R5, TAS2R10, TAS2R50 MAPT 3167/4885ALDH1A1 664/4885HPGD 2448/4885
US-20130041046-A1 SWEET FLAVOR MODIFIER TAS2R5, TAS2R10, TAS2R50 MAPT 2747/4885ALDH1A1 589/4885HPGD 2453/4885
US-11129397-B2 Method of improving stability of sweet enhancer and composition containing stabilized sweet enhancer TFEB, TREH, SLC2A8 MAPT 1864/4885ALDH1A1 3324/4885HPGD 3816/4885
US-20190208802-A1 METHOD OF IMPROVING STABILITY OF SWEET ENHANCER AND COMPOSITION CONTAINING STABILIZED SWEET ENHANCER TFEB, TREH, SLC2A8 MAPT 1864/4885ALDH1A1 3324/4885HPGD 3816/4885
US-20160251372-A1 SWEET FLAVOR MODIFIER TAS2R5, TAS2R10, TAS2R50 MAPT 3167/4885ALDH1A1 664/4885HPGD 2448/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.