Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 7/20 | 0.58 |
| ▸ | LMNA | P02545 | 6/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.58 |
| ▸ | RAB9A | P51151 | 3/20 | 0.53 |
| ▸ | NPC1 | O15118 | 1/20 | 0.53 |
| ▸ | HPGD | P15428 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | CA12 | O43570 | 2/20 | 0.48 |
| ▸ | CA9 | Q16790 | 2/20 | 0.48 |
| ▸ | CA1 | P00915 | 1/20 | 0.48 |
| ▸ | CA2 | P00918 | 1/20 | 0.47 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.47 |
| ▸ | SLC22A8 | Q8TCC7 | 1/20 | 0.47 |
| ▸ | ABCC2 | Q92887 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4394070 | 0.83 | MAPT (0.48) | HTTLMNASMN1; SMN2RAB9ANPC1 | |
| SCHEMBL9962909 | 0.77 | HTT (0.68) | HTTLMNASMN1; SMN2RAB9ANPC1 | |
| Etebenecid SCHEMBL1643610 | 0.77 | SMN1; SMN2 (0.75) | HTTLMNASMN1; SMN2RAB9ANPC1 | |
| SCHEMBL4095461 | 0.77 | ENPP2 (0.48) | KMT2A | |
| SCHEMBL10154240 | 0.77 | CA12 (0.77) | HTTLMNASMN1; SMN2RAB9AHPGD | |
| Hydrochloric Acid SCHEMBL9191431 | 0.76 | HTT (0.60) | HTTLMNASMN1; SMN2RAB9AALDH1A1 | |
| SCHEMBL4638414 | 0.76 | HTT (0.61) | HTTLMNASMN1; SMN2RAB9ANPC1 | |
| SCHEMBL2492611 | 0.76 | HTT (0.61) | HTTLMNASMN1; SMN2RAB9ANPC1 | |
| SCHEMBL13545215 | 0.76 | HTT (0.61) | HTTLMNASMN1; SMN2RAB9ANPC1 | |
| SCHEMBL4397065 | 0.75 | CASP3 (0.46) | HTTLMNARAB9AHPGDALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1959951-B1 | HETEROARYL SUBSTITUTED PIPERIDINE DERIVATIVES AS L-CPT1 INHIBITORS | HOFFMANN LA ROCHE (CH) | 2009-12-23 | — | — | EP | disclosed |