Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.47 |
| ▸ | LMNA | P02545 | 3/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | ATM | Q13315 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4394101 | 0.83 | HTT (0.58) | MAPTALDH1A1SMN1; SMN2LMNAHTT | |
| SCHEMBL4095461 | 0.79 | ENPP2 (0.48) | — | |
| SCHEMBL4397065 | 0.78 | CASP3 (0.46) | MAPTALDH1A1LMNAHTTL3MBTL1 | |
| SCHEMBL3552882 | 0.76 | SMN1; SMN2 (0.52) | ALDH1A1SMN1; SMN2LMNAHTTL3MBTL1 | |
| SCHEMBL312685 | 0.76 | CA2 (0.60) | — | |
| SCHEMBL6855109 | 0.76 | SMN1; SMN2 (0.54) | MAPTHSD17B10ALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL5249012 | 0.75 | SMN1; SMN2 (0.57) | MAPTHSD17B10ALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL14973311 | 0.73 | TSHR (0.60) | ALDH1A1SMN1; SMN2NPSR1TSHRPOLB | |
| SCHEMBL5561006 | 0.73 | SMN1; SMN2 (0.56) | MAPTHSD17B10ALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL34672 | 0.73 | ALDH1A1 (0.66) | MAPTHSD17B10ALDH1A1SMN1; SMN2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1959951-B1 | HETEROARYL SUBSTITUTED PIPERIDINE DERIVATIVES AS L-CPT1 INHIBITORS | HOFFMANN LA ROCHE (CH) | 2009-12-23 | — | — | EP | disclosed |
| CN-101321525-A | Heteroaryl substituted piperidine derivatives as L-CPT1 inhibitors | HOFFMANN LA ROCHE (CH) | 2008-12-10 | — | — | CN | disclosed |