Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | G6PD | P11413 | 1/20 | 0.54 |
| ▸ | TSHR | P16473 | 1/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | MAOB | P27338 | 2/20 | 0.45 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.44 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.43 |
| ▸ | G6PC1 | P35575 | 1/20 | 0.42 |
| ▸ | AHR | P35869 | 1/20 | 0.42 |
| ▸ | IDO1 | P14902 | 1/20 | 0.41 |
| ▸ | TDO2 | P48775 | 1/20 | 0.41 |
| ▸ | PPARG | P37231 | 1/20 | 0.41 |
| ▸ | EGFR | P00533 | 1/20 | 0.41 |
| ▸ | MMP1 | P03956 | 1/20 | 0.41 |
| ▸ | MMP2 | P08253 | 1/20 | 0.41 |
| ▸ | MMP9 | P14780 | 1/20 | 0.41 |
| ▸ | CES2 | O00748 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1202896 | 0.88 | HSD17B10 (0.58) | G6PDCYP1A2HSD17B10MAPTMAOB | |
| SCHEMBL9140874 | 0.87 | CYP1A2 (0.71) | G6PDTSHRCYP1A2HSD17B10MAPT | |
| SCHEMBL2357484 | 0.85 | ALDH1A1 (0.50) | TSHRCYP1A2MAPTMAOBLMNA | |
| SCHEMBL699518 | 0.83 | AHR (0.61) | TSHRCYP1A2MAPTMAOBCYP1B1 | |
| SCHEMBL14947044 | 0.83 | AHR (0.61) | TSHRCYP1A2MAPTMAOBCYP1B1 | |
| SCHEMBL699519 | 0.83 | AHR (0.61) | TSHRCYP1A2MAPTMAOBCYP1B1 | |
| SCHEMBL18416526 | 0.83 | AHR (0.61) | TSHRCYP1A2MAPTMAOBCYP1B1 | |
| SCHEMBL1302 | 0.82 | ALDH1A1 (0.53) | TSHRCYP1A2MAPTMAOBLMNA | |
| SCHEMBL2093969 | 0.80 | CHRM5 (0.54) | CYP1A2HSD17B10MAPTMAOBAHR | |
| SCHEMBL2481252 | 0.79 | AHR (0.44) | G6PDTSHRCYP1A2MAOBAHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 328 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115068587-A | Glycopeptide compound with antiviral activity and application thereof | 上海来益生物药物研究开发中心有限责任公司 | 2022-09-20 | — | — | CN | claimed |
| CN-107790186-B | Novel decamethyl cyclopentadienyl zirconium complex and preparation method and application thereof | 山西医科大学 | 2020-10-30 | — | — | CN | claimed |
| US-10556914-B2 | Substituted isoxazolopyridazinones and isothiazolopyridazinones and methods of use | ABBVIE INC. (US) | 2020-02-11 | — | — | US | claimed |
| EP-3350187-A1 | SUBSTITUTED ISOXAZOLOPYRIDAZINONES AND ISOTHIAZOLOPYRIDAZINONES AND METHODS OF USE | AbbVie Inc. (US) | 2018-07-25 | — | — | EP | claimed |
| CN-107790186-A | A kind of new decamethyl Zirconocenes and its preparation method and application | 山西医科大学 | 2018-03-13 | — | — | CN | claimed |
| WO-2017199103-A1 | BENZAMIDE COMPOUNDS AS ROR GAMMA MODULATORS | GLENMARK PHARMACEUTICALS S.A. (CH) | 2017-11-23 | — | — | WO | claimed |
| WO-2017046117-A1 | SUBSTITUTED ISOXAZOLOPYRIDAZINONES AND ISOTHIAZOLOPYRIDAZINONES AND METHODS OF USE | ABBVIE INC. (US) | 2017-03-23 | — | — | WO | claimed |
| US-20170073353-A1 | SUBSTITUTED ISOXAZOLOPYRIDAZINONES AND ISOTHIAZOLOPYRIDAZINONES AND METHODS OF USE | AbbVie Deutschland GmbH & Co. KG (DE) | 2017-03-16 | — | — | US | claimed |
| EP-2906970-B1 | HIGH REFRACTIVE INDEX OPHTHALMIC DEVICE MATERIALS WITH REDUCED TACK | NOVARTIS AG (CH) | 2016-11-23 | — | — | EP | claimed |
| CN-105859606-A | Piperazinyl-containing indole derivatives, and preparation method and application thereof | 沈阳药科大学 | 2016-08-17 | — | — | CN | claimed |
| EP-0505014-A2 | Novel tetracyclic compounds having anti-allergic and anti-asthmatic activities, their preparation and use | Sankyo Company Limited (JP) | 1992-09-23 | — | — | EP | claimed |
| US-5147876-A | Nervous system disorders | MITSUI PETROCHEMICAL INDUSTRIES, LTD. (JP) | 1992-09-15 | — | — | US | claimed |
| US-5126340-A | Antidepressants | AMERICAN CYANAMID COMPANY (US) | 1992-06-30 | — | — | US | claimed |
| EP-0421823-A2 | Novel tetracyclic compounds having anti-allergic and anti-asthmatic activities, their preparation and use | Sankyo Company Limited (JP) | 1991-04-10 | — | — | EP | claimed |
| US-4963552-A | HYPOTENSIVE AGENTS, ANTIDEPRESSANTS | AMERICAN CYANAMID COMPANY (US) | 1990-10-16 | — | — | US | claimed |
| EP-0379806-A2 | Pyrimidines and their pharmaceutical acceptable salts, and their use as medicines | MITSUI PETROCHEMICAL INDUSTRIES, LTD. (JP) | 1990-08-01 | — | — | EP | claimed |
| US-4927829-A | Heterocyclic compounds and antiulcer agents | SHIONOGI & CO., LTD. (JP) | 1990-05-22 | — | — | US | claimed |
| EP-0264773-A1 | 4,5-dihydro and 4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidines | AMERICAN CYANAMID COMPANY (US) | 1988-04-27 | — | — | EP | claimed |
| EP-0023093-B1 | PENICILLANIC ACID DERIVATIVES, THEIR PREPARATION AND THEIR PHARMACEUTICAL COMPOSITIONS WITH A PENICILLIN OR CEPHALOSPORIN | BEECHAM GROUP PLC (GB) | 1983-09-28 | — | — | EP | claimed |
| US-4258188-A | HYPOTENSIVE AGENTS | AMERICAN HOME PRODUCTS CORPORATION (US) | 1981-03-24 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10556914-B2 | Substituted isoxazolopyridazinones and isothiazolopyridazinones and methods of use | GABRB1, GABBR1, GABBR2 | G6PD 1118/4885TSHR 318/4885CYP1A2 272/4885 |
| US-20170073353-A1 | SUBSTITUTED ISOXAZOLOPYRIDAZINONES AND ISOTHIAZOLOPYRIDAZINONES AND METHODS OF USE | GABRB1, GABBR1, GABBR2 | G6PD 1118/4885TSHR 318/4885CYP1A2 272/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.