Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 7/20 | 0.33 |
| ▸ | DRD3 | P35462 | 7/20 | 0.33 |
| ▸ | HTR2A | P28223 | 6/20 | 0.33 |
| ▸ | MAOB | P27338 | 3/20 | 0.33 |
| ▸ | DRD4 | P21917 | 1/20 | 0.32 |
| ▸ | ADRB3 | P13945 | 4/20 | 0.32 |
| ▸ | ADRB2 | P07550 | 3/20 | 0.32 |
| ▸ | ADRB1 | P08588 | 3/20 | 0.32 |
| ▸ | MAOA | P21397 | 1/20 | 0.32 |
| ▸ | HTR1A | P08908 | 1/20 | 0.31 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.31 |
| ▸ | ACHE | P22303 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4396633 | 0.93 | SOS1 (0.34) | MAOBADRB3ADRB2ADRB1MAOA | |
| SCHEMBL4409298 | 0.93 | MCHR1 (0.35) | HTR1A | |
| SCHEMBL4397029 | 0.93 | DRD2 (0.33) | DRD2DRD3HTR2AMAOBDRD4 | |
| SCHEMBL4398647 | 0.93 | KDM4E (0.33) | MAOBADRB3ADRB2ADRB1HTR1A | |
| SCHEMBL4404545 | 0.92 | MAOB (0.39) | MAOBADRB3ADRB2ADRB1ACHE | |
| Hydrochloric Acid SCHEMBL4541892 | 0.92 | SOS1 (0.33) | MAOBMAOAHTR1A | |
| Hydrochloric Acid SCHEMBL4412704 | 0.92 | HTR1A (0.31) | HTR1ASLC6A4 | |
| SCHEMBL4410335 | 0.92 | MCHR1 (0.33) | ADRB3ADRB2ADRB1HTR1ASLC6A4 | |
| SCHEMBL4401792 | 0.92 | DRD2 (0.35) | DRD2DRD3HTR2AMAOBDRD4 | |
| SCHEMBL914986 | 0.90 | KMT2A (0.37) | DRD2DRD3HTR2AMAOBDRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1720859-B1 | CHEMOKINE RECEPTOR ANTAGONISTS | NOVARTIS AG (CH) | 2009-12-23 | — | — | EP | claimed |