Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCHR1 | Q99705 | 2/20 | 0.39 |
| ▸ | CCR8 | P51685 | 3/20 | 0.38 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.37 |
| ▸ | FAAH | O00519 | 5/20 | 0.35 |
| ▸ | HTR1A | P08908 | 1/20 | 0.35 |
| ▸ | DRD2 | P14416 | 1/20 | 0.35 |
| ▸ | HTR7 | P34969 | 1/20 | 0.35 |
| ▸ | HTR6 | P50406 | 1/20 | 0.35 |
| ▸ | PLD2 | O14939 | 1/20 | 0.35 |
| ▸ | PLD1 | Q13393 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4399208 | 0.93 | CCR3 (0.39) | CCR8SIGMAR1HTR1ADRD2HTR7 | |
| SCHEMBL4406827 | 0.91 | HTR7 (0.44) | MCHR1CCR8SIGMAR1HTR1ADRD2 | |
| SCHEMBL4406826 | 0.90 | HTR7 (0.40) | CCR8SIGMAR1FAAHHTR1ADRD2 | |
| SCHEMBL4409097 | 0.89 | CCR8 (0.44) | CCR8FAAH | |
| SCHEMBL4403841 | 0.88 | CCR8 (0.39) | MCHR1CCR8FAAH | |
| SCHEMBL4404557 | 0.88 | CCR8 (0.43) | MCHR1CCR8FAAHHTR1AHTR7 | |
| SCHEMBL915415 | 0.87 | MCHR1 (0.45) | MCHR1CCR8HTR1ADRD2HTR7 | |
| SCHEMBL4401901 | 0.84 | HTR4 (0.46) | CCR8SIGMAR1DRD2 | |
| SCHEMBL4398634 | 0.84 | HTR7 (0.44) | CCR8SIGMAR1HTR1ADRD2HTR7 | |
| SCHEMBL4409226 | 0.83 | HTR7 (0.40) | CCR8SIGMAR1FAAHHTR1ADRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1720859-B1 | CHEMOKINE RECEPTOR ANTAGONISTS | NOVARTIS AG (CH) | 2009-12-23 | — | — | EP | claimed |