Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR4 | Q13639 | 3/20 | 0.46 |
| ▸ | MTNR1A | P48039 | 2/20 | 0.45 |
| ▸ | MTNR1B | P49286 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.43 |
| ▸ | DRD2 | P14416 | 1/20 | 0.42 |
| ▸ | DRD3 | P35462 | 1/20 | 0.42 |
| ▸ | CCR8 | P51685 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.41 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | APLNR | P35414 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4405558 | 0.90 | HTR4 (0.39) | HTR4CCR8SMN1; SMN2KDM4EHSD17B10 | |
| SCHEMBL4551166 | 0.88 | LMNA (0.42) | HTR4DRD3CCR8HTTALDH1A1 | |
| SCHEMBL4405631 | 0.88 | SSTR4 (0.40) | HTR4 | |
| SCHEMBL4402091 | 0.88 | LMNA (0.42) | HTR4DRD3CCR8HTTALDH1A1 | |
| SCHEMBL4404430 | 0.88 | HTR4 (0.37) | HTR4DRD2 | |
| SCHEMBL4409097 | 0.88 | CCR8 (0.44) | KMT2ACCR8SMN1; SMN2HPGDALDH1A1 | |
| SCHEMBL4405570 | 0.88 | TLR7 (0.43) | HTR4KMT2ACCR8SMN1; SMN2NPSR1 | |
| SCHEMBL4403841 | 0.88 | CCR8 (0.39) | HTR4CCR8KDM4E | |
| SCHEMBL4403442 | 0.87 | ADRB2 (0.40) | HTR4HRH4SMN1; SMN2KDM4ESIGMAR1 | |
| SCHEMBL4400739 | 0.87 | GUCY1B2 (0.37) | HTR4MTNR1AMTNR1BDRD2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1720859-B1 | CHEMOKINE RECEPTOR ANTAGONISTS | NOVARTIS AG (CH) | 2009-12-23 | — | — | EP | claimed |