Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR3 | P51677 | 2/20 | 0.39 |
| ▸ | SIGMAR1 | Q99720 | 6/20 | 0.39 |
| ▸ | HTR2A | P28223 | 2/20 | 0.39 |
| ▸ | HTR7 | P34969 | 4/20 | 0.38 |
| ▸ | HTR1A | P08908 | 3/20 | 0.38 |
| ▸ | DRD2 | P14416 | 2/20 | 0.38 |
| ▸ | HTR6 | P50406 | 2/20 | 0.38 |
| ▸ | CCR8 | P51685 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.37 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.37 |
| ▸ | DRD1 | P21728 | 1/20 | 0.37 |
| ▸ | DRD4 | P21917 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4406826 | 0.94 | HTR7 (0.40) | CCR3SIGMAR1HTR7HTR1ADRD2 | |
| SCHEMBL4406827 | 0.93 | HTR7 (0.44) | CCR3SIGMAR1HTR7HTR1ADRD2 | |
| SCHEMBL4409097 | 0.93 | CCR8 (0.44) | CCR3CCR8MEN1ALDH1A1HPGD | |
| SCHEMBL4396955 | 0.93 | MCHR1 (0.39) | SIGMAR1HTR7HTR1ADRD2HTR6 | |
| SCHEMBL4403841 | 0.92 | CCR8 (0.39) | CCR8SLC6A3SLC18A2 | |
| SCHEMBL4404557 | 0.88 | CCR8 (0.43) | HTR7HTR1ACCR8MEN1MAPT | |
| SCHEMBL4409226 | 0.87 | HTR7 (0.40) | CCR3SIGMAR1HTR7HTR1ADRD2 | |
| SCHEMBL4401901 | 0.87 | HTR4 (0.46) | SIGMAR1DRD2CCR8ALDH1A1HPGD | |
| SCHEMBL4398634 | 0.86 | HTR7 (0.44) | CCR3SIGMAR1HTR7HTR1ADRD2 | |
| SCHEMBL4542491 | 0.86 | HTR7 (0.37) | CCR3SIGMAR1HTR7HTR1ADRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1720859-B1 | CHEMOKINE RECEPTOR ANTAGONISTS | NOVARTIS AG (CH) | 2009-12-23 | — | — | EP | claimed |