Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR8 | P51685 | 2/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.38 |
| ▸ | FLT3 | P36888 | 1/20 | 0.38 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.37 |
| ▸ | HTR4 | Q13639 | 1/20 | 0.37 |
| ▸ | FAAH | O00519 | 2/20 | 0.36 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.36 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.36 |
| ▸ | SLC18A2 | Q05940 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4400741 | 0.93 | L3MBTL1 (0.39) | CCR8L3MBTL1FAAHSLC6A3SLC18A2 | |
| SCHEMBL4404557 | 0.92 | CCR8 (0.43) | CCR8L3MBTL1FAAHMCHR1KDM4E | |
| SCHEMBL4399208 | 0.92 | CCR3 (0.39) | CCR8SLC6A3SLC18A2 | |
| SCHEMBL4409097 | 0.92 | CCR8 (0.44) | CCR8FAAH | |
| SCHEMBL4411263 | 0.92 | SLC6A3 (0.37) | CCR8L3MBTL1FAAHSLC6A3SLC18A2 | |
| SCHEMBL4396955 | 0.88 | MCHR1 (0.39) | CCR8FAAHMCHR1 | |
| SCHEMBL4406826 | 0.88 | HTR7 (0.40) | CCR8FLT3FAAH | |
| SCHEMBL4401901 | 0.88 | HTR4 (0.46) | CCR8HTR4KDM4E | |
| SCHEMBL4406827 | 0.87 | HTR7 (0.44) | CCR8MCHR1 | |
| SCHEMBL914958 | 0.86 | PDGFRB (0.45) | CCR8PDGFRBFLT3HTR4MCHR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1720859-B1 | CHEMOKINE RECEPTOR ANTAGONISTS | NOVARTIS AG (CH) | 2009-12-23 | — | — | EP | claimed |