Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F10 | P00742 | 14/20 | 0.56 |
| ▸ | F2 | P00734 | 11/20 | 0.56 |
| ▸ | PRSS1 | P07477 | 10/20 | 0.56 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.46 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.46 |
| ▸ | PRSS2 | P07478 | 6/20 | 0.44 |
| ▸ | PRSS3 | P35030 | 6/20 | 0.44 |
| ▸ | PLG | P00747 | 1/20 | 0.44 |
| ▸ | C1S | P09871 | 1/20 | 0.40 |
| ▸ | HPN | P05981 | 4/20 | 0.40 |
| ▸ | HGFAC | Q04756 | 4/20 | 0.40 |
| ▸ | ST14 | Q9Y5Y6 | 4/20 | 0.40 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4392508 | 0.83 | DDB1 (0.40) | F10F2PRSS1DDB1CRBN | |
| SCHEMBL3553878 | 0.82 | ALDH1A1 (0.57) | DDB1CRBN | |
| SCHEMBL7257909 | 0.78 | DDB1 (0.71) | DDB1CRBN | |
| SCHEMBL8076294 | 0.76 | DDB1 (0.47) | DDB1CRBN | |
| SCHEMBL3552569 | 0.75 | DDB1 (0.39) | DDB1CRBN | |
| SCHEMBL1788429 | 0.73 | MEN1 (0.58) | DDB1CRBN | |
| SCHEMBL5182235 | 0.73 | DDB1 (0.47) | DDB1CRBN | |
| Hydantoin SCHEMBL3552566 | 0.73 | ALDH1A1 (0.48) | DDB1CRBN | |
| SCHEMBL23751202 | 0.72 | PLAU (0.60) | F10F2PRSS1PLGKLKB1 | |
| SCHEMBL746783 | 0.71 | CRBN (0.66) | DDB1CRBN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101321525-B | Heteroaryl substituted piperidine derivatives as L-CPT1 inhibitors | HOFFMANN LA ROCHE | 2013-01-30 | — | — | CN | disclosed |
| EP-1959951-B1 | HETEROARYL SUBSTITUTED PIPERIDINE DERIVATIVES AS L-CPT1 INHIBITORS | HOFFMANN LA ROCHE (CH) | 2009-12-23 | — | — | EP | disclosed |
| CN-101321525-A | Heteroaryl substituted piperidine derivatives as L-CPT1 inhibitors | HOFFMANN LA ROCHE (CH) | 2008-12-10 | — | — | CN | disclosed |