Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 3/20 | 0.37 |
| ▸ | MCHR1 | Q99705 | 2/20 | 0.37 |
| ▸ | DRD2 | P14416 | 1/20 | 0.36 |
| ▸ | DRD3 | P35462 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 2/20 | 0.34 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.34 |
| ▸ | SIGMAR1 | Q99720 | 7/20 | 0.33 |
| ▸ | CCR8 | P51685 | 1/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | HTR4 | Q13639 | 1/20 | 0.32 |
| ▸ | MAOA | P21397 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4406815 | 0.93 | KDM4E (0.36) | MAOBMCHR1DRD2DRD3CD274 | |
| SCHEMBL4400742 | 0.92 | MCHR1 (0.36) | MAOBMCHR1POLBSIGMAR1USP2 | |
| Hydrochloric Acid SCHEMBL4406781 | 0.92 | MAOB (0.34) | MAOBMCHR1DRD2DRD3POLB | |
| SCHEMBL4401840 | 0.90 | MAOB (0.44) | MAOBMCHR1DRD2DRD3SIGMAR1 | |
| SCHEMBL4409300 | 0.89 | MAOB (0.44) | MAOBMCHR1DRD2DRD3SIGMAR1 | |
| SCHEMBL914118 | 0.89 | DRD2 (0.41) | MAOBMCHR1DRD2DRD3POLB | |
| Hydrochloric Acid SCHEMBL4406795 | 0.86 | HTR1A (0.39) | MCHR1DRD2DRD3CCR8KMT2A | |
| SCHEMBL4405632 | 0.86 | MAOB (0.38) | MAOBDRD2DRD3MAOA | |
| SCHEMBL4394210 | 0.86 | MCHR1 (0.34) | MAOBMCHR1KMT2AKDM4EALDH1A1 | |
| Hydrochloric Acid SCHEMBL4396580 | 0.86 | HTR7 (0.33) | MAOBMCHR1DRD2DRD3SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1720859-B1 | CHEMOKINE RECEPTOR ANTAGONISTS | NOVARTIS AG (CH) | 2009-12-23 | — | — | EP | claimed |