Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSK | P43235 | 1/20 | 0.64 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.50 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.48 |
| ▸ | MEF2D | Q14814 | 1/20 | 0.48 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.48 |
| ▸ | MMP2 | P08253 | 1/20 | 0.47 |
| ▸ | MMP9 | P14780 | 1/20 | 0.47 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.46 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.46 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.46 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.46 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.46 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.46 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.46 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.46 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.46 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.46 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.46 |
| ▸ | ERAP2 | Q6P179 | 2/20 | 0.45 |
| ▸ | LNPEP | Q9UIQ6 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8772974 | 1.00 | CTSK (0.64) | CTSKGRIA1HDAC4MEF2DEPHX2 | |
| SCHEMBL825451 | 1.00 | CTSK (0.64) | CTSKGRIA1HDAC4MEF2DEPHX2 | |
| SCHEMBL7036665 | 0.86 | CTSK (0.53) | CTSKGRIA1HDAC4MEF2DHDAC1 | |
| SCHEMBL7036660 | 0.86 | CTSK (0.53) | CTSKGRIA1HDAC4MEF2DHDAC1 | |
| SCHEMBL8177757 | 0.86 | SMN1; SMN2 (0.60) | CTSKGRIA1HDAC4EPHX2HDAC1 | |
| SCHEMBL8861463 | 0.85 | EPHX2 (0.50) | CTSKGRIA1HDAC4EPHX2HDAC1 | |
| SCHEMBL8177140 | 0.85 | SMN1; SMN2 (0.59) | CTSKGRIA1HDAC4EPHX2HDAC1 | |
| SCHEMBL7036651 | 0.83 | SLC6A5 (0.52) | CTSKHDAC4MEF2DHDAC1SMN1; SMN2 | |
| SCHEMBL7034276 | 0.83 | P2RX7 (0.52) | CTSKMMP2MMP9FOLH1ERAP2 | |
| SCHEMBL7034270 | 0.83 | P2RX7 (0.52) | CTSKMMP2MMP9FOLH1ERAP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 25 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1909814-B1 | Peptides for induction and enhancement of apoptosis in tumor cells | GEORG AUGUST UNIVERSITÄT GÖTTINGEN STIFTUNG ÖFFENTLICHEN RECHTS OHNE BEREICH HUMANMEDIZIN (DE) | 2015-06-24 | — | — | EP | disclosed |
| EP-1778278-B1 | GONADOTROPIN RELEASING HORMONE ANTAGONISTS | OAKWOOD LAB L L C (US) | 2014-05-21 | — | — | EP | disclosed |
| US-8334258-B2 | Administering gonadotropin-hormone-releasing hormone (GnRH) antagonist peptide for inducing/enhancing apoptosis of breast cancer or malignant melanoma or gynaecological cancer | GEORG-AUGUST-UNIVERSITÄT GÖTTINGEN STIFTUNG ÖFFENTLICHEN RECHTS (UNIVERSITÄTSMEDIZIN) (DE) | 2012-12-18 | — | — | US | disclosed |
| US-8329863-B2 | Gonadotropin releasing hormone antagonists | OAKWOOD LABORATORIES, LLC (US) | 2012-12-11 | — | — | US | disclosed |
| US-20090105153-A1 | Gonadotropin Releasing Hormone Antagonists | ALFERA PHARMACEUTICALS, LLC | 2009-04-23 | — | — | US | disclosed |
| US-20080167250-A1 | Method For Induction and Enhancement of Apoptosis In Tumor Cells | GEORG-AUGUST-UNIVERSITAET GOETTINGEN, STIFTUNG OEFFENTLECHEN RECHTS, BEREICH HUMANMEDIZIN (DE) | 2008-07-10 | — | — | US | disclosed |
| EP-1909814-A1 | METHOD FOR INDUCTION AND ENHANCEMENT OF APOPTOSIS IN TUMOR CELLS | Georg-August-Universität Göttingen Stiftung des Öffentlichen Rechts (Bereich Humanmedizin) (DE) | 2008-04-16 | — | — | EP | disclosed |
| EP-1778278-A2 | GONADOTROPIN RELEASING HORMONE ANTAGONISTS | Oakwood Laboratories L.L.C. (US) | 2007-05-02 | — | — | EP | disclosed |
| WO-2007012430-A1 | METHOD FOR INDUCTION AND ENHANCEMENT OF APOPTOSIS IN TUMOR CELLS | GEORG-AUGUST-UNIVERSITÄT-GÖTTINGEN (DE) | 2007-02-01 | — | — | WO | disclosed |
| US-7122628-B2 | Process for the synthesis of a peptide having a Trp residue | IPSEN MANUFACTURING IRELAND, LIMITED (IE) | 2006-10-17 | — | — | US | disclosed |
| WO-2002051861-A2 | PROCESS FOR THE SYNTHESIS OF A PEPTIDE HAVING A TRYPTOPHAN RESIDUE | KINERTON LIMITED (IE) | 2002-07-04 | — | — | WO | disclosed |
| EP-0822827-A4 | ANTAGONISTS OF LHRH | UNIV TEXAS (US) | 2001-07-11 | — | — | EP | disclosed |
| EP-0937101-B1 | CONFORMATIONALLY CONSTRAINED LH-RH ANALOGUES, THEIR USES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | THERAMEX (MC) | 2000-10-11 | — | — | EP | disclosed |
| EP-0937101-A1 | CONFORMATIONALLY CONSTRAINED LH-RH ANALOGUES, THEIR USES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | LABORATOIRE THERAMEX (MC) | 1999-08-25 | — | — | EP | disclosed |
| WO-1998021229-A1 | CONFORMATIONALLY CONSTRAINED LH-RH ANALOGUES, THEIR USES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | LABORATOIRE THERAMEX (MC) | 1998-05-22 | — | — | WO | disclosed |
| EP-0842946-A1 | Conformationally constrained LH-RH analogues, their uses and pharmaceutical compositions containing them | LABORATOIRE THERAMEX S.A. (MC) | 1998-05-20 | — | — | EP | disclosed |
| EP-0822827-A1 | ANTAGONISTS OF LHRH | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) | 1998-02-11 | — | — | EP | disclosed |
| WO-1996033729-A1 | ANTAGONISTS OF LHRH | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) | 1996-10-31 | — | — | WO | disclosed |
| EP-0536203-B1 | COMBINED TREATMENT WITH GnRH ANTAGONIST AND GnRH TO CONTROL GONADOTROPIN LEVELS IN MAMMALS | APPLIED RESEARCH SYSTEMS (AN) | 1995-02-08 | — | — | EP | disclosed |
| WO-1991019743-A2 | COMBINED TREATMENT WITH GnRH ANTAGONIST AND GnRH TO CONTROL GONADOTROPIN LEVELS IN MAMMALS | APPLIED RESEARCH SYSTEMS ARS HOLDING N.V. (AN) | 1991-12-26 | — | — | WO | disclosed |