Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 9/20 | 0.49 |
| ▸ | TP53 | P04637 | 7/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.43 |
| ▸ | THRB | P10828 | 1/20 | 0.42 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL44862 | 0.83 | GAA (0.47) | MAPTLMNASMN1; SMN2TP53KDM4E | |
| SCHEMBL39342 | 0.82 | CYP19A1 (0.53) | MAPTLMNASMN1; SMN2TP53KDM4E | |
| SCHEMBL45277 | 0.82 | TP53 (0.49) | MAPTLMNATP53KDM4EKMT2A | |
| SCHEMBL44674 | 0.81 | MAPT (0.52) | MAPTSMN1; SMN2TP53 | |
| SCHEMBL44856 | 0.81 | F3 (0.51) | MAPTLMNASMN1; SMN2TP53 | |
| SCHEMBL44483 | 0.81 | RAB9A (0.52) | MAPTSMN1; SMN2TP53KDM4ETDP1 | |
| SCHEMBL38543 | 0.81 | WDR5 (0.45) | MAPT | |
| SCHEMBL44495 | 0.81 | WDR5 (0.55) | MAPTSMN1; SMN2KDM4ERXFP1KMT2A | |
| SCHEMBL45795 | 0.79 | CHRM3 (0.49) | MAPTLMNASMN1; SMN2TP53KDM4E | |
| SCHEMBL13844857 | 0.78 | WDR5 (0.51) | TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011137587-A1 | CYTOKINE INHIBITORS | HUTCHISON MEDIPHARMA LIMITED (CN) | 2011-11-10 | — | — | WO | claimed |
| WO-2011137587-A1 | CYTOKINE INHIBITORS | HUTCHISON MEDIPHARMA LIMITED (CN) | 2011-11-10 | — | — | WO | disclosed |