Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.52 |
| ▸ | TP53 | P04637 | 2/20 | 0.52 |
| ▸ | POLB | P06746 | 2/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
| ▸ | F3 | P13726 | 1/20 | 0.51 |
| ▸ | ROCK2 | O75116 | 7/20 | 0.50 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.50 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.48 |
| ▸ | NAMPT | P43490 | 2/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | WDR5 | P61964 | 1/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL44483 | 0.87 | RAB9A (0.52) | MAPTTP53SMN1; SMN2ROCK2EPHB4 | |
| SCHEMBL44856 | 0.86 | F3 (0.51) | MAPTTP53POLBSMN1; SMN2F3 | |
| SCHEMBL44054 | 0.81 | MAPT (0.53) | MAPTTP53SMN1; SMN2 | |
| SCHEMBL38543 | 0.80 | WDR5 (0.45) | MAPTPOLBRAB9AWDR5 | |
| SCHEMBL44862 | 0.79 | GAA (0.47) | MAPTTP53POLBSMN1; SMN2RAB9A | |
| SCHEMBL19997616 | 0.78 | WDR5 (0.75) | WDR5 | |
| SCHEMBL45277 | 0.77 | TP53 (0.49) | MAPTTP53POLBRAB9AWDR5 | |
| SCHEMBL39660 | 0.76 | CYP19A1 (0.56) | MAPTTP53POLB | |
| SCHEMBL44495 | 0.76 | WDR5 (0.55) | MAPTPOLBSMN1; SMN2WDR5 | |
| SCHEMBL45795 | 0.75 | CHRM3 (0.49) | MAPTTP53SMN1; SMN2WDR5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011137587-A1 | CYTOKINE INHIBITORS | HUTCHISON MEDIPHARMA LIMITED (CN) | 2011-11-10 | — | — | WO | claimed |
| WO-2011137587-A1 | CYTOKINE INHIBITORS | HUTCHISON MEDIPHARMA LIMITED (CN) | 2011-11-10 | — | — | WO | disclosed |
| WO-2011137587-A1 | CYTOKINE INHIBITORS | HUTCHISON MEDIPHARMA LIMITED (CN) | 2011-11-10 | — | — | WO | disclosed |