Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 4/20 | 0.52 |
| ▸ | NPC1 | O15118 | 3/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.52 |
| ▸ | MAPT | P10636 | 2/20 | 0.52 |
| ▸ | MEN1 | O00255 | 2/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | THRB | P10828 | 1/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.52 |
| ▸ | MTOR | P42345 | 1/20 | 0.48 |
| ▸ | EPHB4 | P54760 | 2/20 | 0.47 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.46 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.46 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.46 |
| ▸ | ABL1 | P00519 | 1/20 | 0.46 |
| ▸ | BCR | P11274 | 1/20 | 0.46 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | NAMPT | P43490 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL44674 | 0.87 | MAPT (0.52) | RAB9ANPC1SMN1; SMN2MAPTEPHB4 | |
| SCHEMBL45795 | 0.82 | CHRM3 (0.49) | SMN1; SMN2MAPTKDM4ETDP1TP53 | |
| SCHEMBL44054 | 0.81 | MAPT (0.53) | SMN1; SMN2MAPTKMT2AKDM4ETHRB | |
| SCHEMBL44862 | 0.80 | GAA (0.47) | RAB9ANPC1SMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL44856 | 0.80 | F3 (0.51) | SMN1; SMN2MAPTEPHB4TP53NAMPT | |
| SCHEMBL45277 | 0.79 | TP53 (0.49) | RAB9AALDH1A1MAPTMEN1KMT2A | |
| SCHEMBL44780 | 0.79 | ALDH1A1 (0.44) | RAB9ANPC1SMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL3667489 | 0.78 | F2RL3 (0.54) | RAB9ANPC1SMN1; SMN2MAPTKMT2A | |
| SCHEMBL38543 | 0.78 | WDR5 (0.45) | RAB9AMAPTMTOR | |
| SCHEMBL44495 | 0.78 | WDR5 (0.55) | SMN1; SMN2ALDH1A1MAPTMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011137587-A1 | CYTOKINE INHIBITORS | HUTCHISON MEDIPHARMA LIMITED (CN) | 2011-11-10 | — | — | WO | claimed |
| WO-2011137587-A1 | CYTOKINE INHIBITORS | HUTCHISON MEDIPHARMA LIMITED (CN) | 2011-11-10 | — | — | WO | disclosed |