Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | WDR5 | P61964 | 5/20 | 0.47 |
| ▸ | TP53 | P04637 | 5/20 | 0.44 |
| ▸ | RAB9A | P51151 | 3/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | BRD4 | O60885 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL45277 | 0.92 | TP53 (0.49) | GAAWDR5TP53RAB9AMAPT | |
| SCHEMBL38543 | 0.89 | WDR5 (0.45) | GAAWDR5RAB9AMAPTHPGD | |
| SCHEMBL44495 | 0.86 | WDR5 (0.55) | WDR5MAPTKDM4EALDH1A1HPGD | |
| SCHEMBL44636 | 0.85 | TP53 (0.43) | GAAWDR5TP53MAPTKDM4E | |
| SCHEMBL44645 | 0.84 | WDR5 (0.51) | WDR5MAPTHPGDPOLBLMNA | |
| SCHEMBL44054 | 0.83 | MAPT (0.53) | TP53MAPTKDM4ESMN1; SMN2LMNA | |
| SCHEMBL45795 | 0.83 | CHRM3 (0.49) | GAAWDR5TP53MAPTKDM4E | |
| SCHEMBL13844857 | 0.82 | WDR5 (0.51) | WDR5TP53RAB9APOLB | |
| SCHEMBL44483 | 0.80 | RAB9A (0.52) | TP53RAB9AMAPTKDM4ENPC1 | |
| SCHEMBL44398 | 0.80 | CHRM3 (0.52) | WDR5TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011137587-A1 | CYTOKINE INHIBITORS | HUTCHISON MEDIPHARMA LIMITED (CN) | 2011-11-10 | — | — | WO | claimed |
| WO-2011137587-A1 | CYTOKINE INHIBITORS | HUTCHISON MEDIPHARMA LIMITED (CN) | 2011-11-10 | — | — | WO | disclosed |
| WO-2011137587-A1 | CYTOKINE INHIBITORS | HUTCHISON MEDIPHARMA LIMITED (CN) | 2011-11-10 | — | — | WO | disclosed |