Oxaloacetate

Oxaloacetate

SCHEMBL4407472

NCC(=O)O.O=C(O)CC(=O)C(=O)O

nearest known ligand 0.59

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Known targets — ChEMBL curated mechanism

ADORA1ADORA2AADORA2BADORA3PDE3APDE3BPDE4APDE4BPDE4CPDE4D

The experimentally established mechanism targets of Oxaloacetate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
OR51E2 Q9H255 3/20 0.59
GLRA1 P23415 1/20 0.59
SLC6A9 P48067 1/20 0.59
LDHA P00338 1/20 0.44
SRR Q9GZT4 1/20 0.44
MAPK1 P28482 1/20 0.41
SLC13A3 Q8WWT9 1/20 0.41
EGLN1 Q9GZT9 1/20 0.41
GABRR1 P24046 3/20 0.38
FEN1 P39748 4/20 0.36
ERCC5 P28715 3/20 0.36
PTPN1 P18031 1/20 0.36
TSHR P16473 2/20 0.35
KDM4E B2RXH2 1/20 0.35
HAO1 Q9UJM8 3/20 0.33
GABRR3 A8MPY1 1/20 0.33
GABRP O00591 1/20 0.33
GABRD O14764 1/20 0.33
HDAC3 O15379 1/20 0.33
GABBR2 O75899 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Oxaloacetate SCHEMBL4298763 0.87 LDHA (0.57) OR51E2GLRA1SLC6A9LDHASRR
Oxaloacetate SCHEMBL898612 0.87 LDHA (0.57) OR51E2GLRA1SLC6A9LDHASRR
Oxaloacetate SCHEMBL8464 0.87
Oxaloacetate SCHEMBL11328361 0.84 LDHA (0.53) OR51E2GLRA1SLC6A9LDHASRR
Oxaloacetate SCHEMBL20912993 0.84 LDHA (0.53) OR51E2GLRA1SLC6A9LDHASRR
Oxaloacetate SCHEMBL25210523 0.84
Oxaloacetate SCHEMBL6545252 0.84 LDHA (0.53) OR51E2GLRA1SLC6A9LDHASRR
Oxaloacetate SCHEMBL9782818 0.84 LDHA (0.53) OR51E2GLRA1SLC6A9LDHASRR
Oxaloacetate SCHEMBL8638879 0.84 LDHA (0.53) OR51E2GLRA1SLC6A9LDHASRR
Oxaloacetate SCHEMBL6545256 0.84 LDHA (0.53) OR51E2GLRA1SLC6A9LDHASRR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11999982-B2 Method for the fermentative production of guanidinoacetic acid EVONIK OPERATIONS GMBH (DE) 2024-06-04 US disclosed
US-20230227795-A1 METHOD FOR THE FERMENTATIVE PRODUCTION OF GUANIDINOACETIC ACID EVONIK OPERATIONS GMBH (DE) 2023-07-20 US disclosed
EP-4163383-A1 MICROBIAL PRODUCTION OF FATTY AMINES Genomatica, Inc. (US) 2023-04-12 EP disclosed
WO-2023015285-A1 MICROORGANISMS AND METHODS FOR IMPROVED BIOLOGICAL PRODUCTION OF ETHYLENE GLYCOL LANZATECH, INC. (US) 2023-02-09 WO disclosed
US-11421223-B2 Processes and host cells for genome, pathway, and biomolecular engineering ENEVOLV, INC. (US) 2022-08-23 US disclosed
US-7635572-B2 Methods for conducting assays for enzyme activity on protein microarrays Life Technologies Corporation (US) 2009-12-22 US disclosed
US-20050118665-A1 Methods for conducting assays for enzyme activity on protein microarrays PROTOMETRIX, INC. 2005-06-02 US disclosed